SSTR3 Antibodies

Somatostatin receptor type 3 (SSTR3)

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

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Gene Information

Human
Gene Name:	SSTR3
Uniprot:	P32745
Entrez:	6753

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

Somatostatin R3; somatostatin receptor 3; SomatostatinR3; SS-3-R; SS3-R; SSR-28; SST3; SSTR3

Molecular Weight

Mass (kDA):
45.847 kDA

Genomic Context

Human
Location:	22q13.1
Sequence:	22; NC_000022.11 (37204237..37220451, complement)

Tissue Specificity

Brain, pituitary and pancreas.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Internalized into endoplasmic vesicles upon somatostatin-stimulation.

Diseases

• Neoplasms
• Pituitary Diseases
• Malignant Neoplasms
• Adenoma
• Carcinoma
• Pituitary Neoplasms
• Pituitary Adenoma
• Nervousness
• Acromegaly
• Adenocarcinoma
• Pertussis
• Neuroendocrine Tumors
• Stomach Neoplasms

• Neoplasm Metastasis
• Malignant Paraganglionic Neoplasm
• Carcinoid Tumor
• Growth Hormone-secreting Pituitary Adenoma
• Liver Neoplasms
• Prolactinoma
• Liver Carcinoma

Interacting Proteins

• MPDZ
• Mpdz
• SSTR2

Pathways

• Secretion
• Localization
• Cell Proliferation
• Hormone Secretion
• Cell Growth
• Reverse Transcription
• Cell Cycle
• Insulin Secretion
• Endocytosis
• Growth Hormone Secretion
• Cell Cycle Arrest
• Angiogenesis
• Gastric Acid Secretion

• Acid Secretion
• Feeding Behavior
• Cell Death
• Exocytosis
• Pathogenesis
• Lymphocyte Activation
• Muscle Contraction

PTMs

• Phosphorylation

Research Areas

• Apoptosis
• Breast Cancer
• GPCR
• Neuronal Cell Markers
• Neuroscience

• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SSTR3

Best Uses Of The SSTR3 Marker

There are many biological tests that use antibodies against SSTR3 markers. However, there are some benefits to using high-affinity SSTR3 markers. Boster Bio creates its antibodies against the receptor using rabbits and mice. Somatostatin blocks enzymes that are critical for calcium entry, such as adenylylcyclase. It also suppresses voltage dependent calcium channels.

Boster Bio's high affinity primary antibodies

Boster Bio's antiSomatostatin Receptor 2/SSTR2 antibody, catalog # PA1694, was designed to recognize target proteins in immunohistochemistry studies. The antibody reacts to human, mouse, rats, and equine specimens. It is compatible for use with ELISA tests. The SSTR3 marker was previously used as a molecular target in immunohistochemistry.

SSTR3 is a marker protein for small intestinal NET. The antibody has strong staining of SSTR4 in (a), as well as SSTR3 in (b). Positive staining was observed in the SSTR3 CHO cell line. Negative staining results when the primary antibody is removed from the experiments.

SSTR3 proteins are expressed in more than half of NET malignancies. Patients with SSA+ tumors had a higher mortality rate than those without the disease. The research team is looking into the possibility of using somatostatin-analogs in patients suffering from advanced NET. To detect this protein in cancer cells, the high-affinity primary antibodies use SSTR3 markers.

These antibodies only contain antigens that are targeted. High antibody affinity makes is difficult to separate antibodies and antigens. High affinity antibodies may require harsh elution or denaturing. Boster Bio's high affinity primary antibodies are made using the SSTR3 marker, regardless of their affinities. This technology helps ensure that the best quality antibodies are produced for cancer immunotherapy.

Permission granted for single print for individual use

This article explains the methods used for locating SSTR3 within the cytoplasm. This marker is found within the cytoplasm in smooth muscle cells and unidentified cell kinds. Most specimens showed mixed subcellular distribution patterns. SSTR2 was also more visible in the cytoplasm and less at the membrane. However, the clinical significance and utility of this marker are not known.

History of Steven Boster

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Steve Boster was a Joliet native. He was the father of several children, including Donald Sr., David Boster and Nina Mae Hall. He was also an active member of Concordia Hall, Staunton. He is survived, in addition to his parents. His family also includes many nieces or nephews.