FACT complex subunit SSRP1 (SSRP1)

The FACT complex is involved in multiple processes that require DNA as a template like mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex functions as a histone chaperone that both destabilizes and restores nucleosomal structure.

It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of'Ser-392' of p53/TP53 through its association with CK2 (casein kinase II).