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- Table of Contents
Facts about Serine/arginine repetitive matrix protein 1.
Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) variables of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex.
Human | |
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Gene Name: | SRRM1 |
Uniprot: | Q8IYB3 |
Entrez: | 10250 |
Belongs to: |
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splicing factor SR family |
MGC39488; POP101; Ser/Arg-related nuclear matrix protein; serine/arginine repetitive matrix 1; serine/arginine repetitive matrix protein 1; SRm160; SRM160160-KD; SR-related nuclear matrix protein of 160 kDa
Mass (kDA):
102.335 kDA
Human | |
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Location: | 1p36.11 |
Sequence: | 1; NC_000001.11 (24643273..24673281) |
Nucleus matrix. Nucleus speckle.
PMID: 9531537 by Blencowe B.J., et al. A coactivator of pre-mRNA splicing.
PMID: 10339552 by Eldridge A.G., et al. The SRm160/300 splicing coactivator is required for exon-enhancer function.