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- Table of Contents
Facts about Signal transducing adapter molecule 2.
May also play a part in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex).
Human | |
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Gene Name: | STAM2 |
Uniprot: | O75886 |
Entrez: | 10254 |
Belongs to: |
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STAM family |
DKFZp564C047; Hbp; Hrs-binding protein; HSE1 homolog; signal transducing adapter molecule 2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; STAM-2; STAM2A; STAM2B; STAM-like protein containing SH3 and ITAM domains 2
Mass (kDA):
58.164 kDA
Human | |
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Location: | 2q23.3 |
Sequence: | 2; NC_000002.12 (152116801..152175777, complement) |
Ubiquitously expressed.
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
PMID: 10899310 by Endo K., et al. STAM2, a new member of the STAM family, binding to the Janus kinases.
PMID: 12551915 by Bache K.G., et al. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.