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SRSF protein kinase 1 Antibodies
AND SRPK1 ELISA kits, SRSF protein kinase 1 Proteins
Many biological assays use antibodies to detect SRSF protein kinase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRSF protein kinase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRSF protein kinase 1 antibodies...
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SRPK1 Infographic by Boster Bio
All SRPK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC-P, WB
$449
Cat # A01937-1
0.1 mg
Cat # A01937-1
0.1 mg
SRPK1 Overview
Facts about SRSF protein kinase 1.
SRSF protein kinase 1 (SRPK1)
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates in serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory system for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles through mitosis.
Can influence additional measures of mRNA maturation, in addition to other mobile activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1.
Gene Information
| Human | |
|---|---|
| Gene Name: | SRPK1 |
| Uniprot: | Q96SB4 |
| Entrez: | 6732 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; Serine/arginine-rich protein-specific kinase 1; serine/arginine-rich splicing factor kinase 1; serine/threonine-protein kinase SRPK1; SFRS protein kinase 1SFRSK1; SR protein kinase 1; SR-protein-specific kinase 1; SRSF protein kinase 1
Molecular Weight
Mass (kDA):
74.325 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.31 |
| Sequence: | 6; NC_000006.12 (35832966..35921180, complement) |
Tissue Specificity
Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1.
Subcellular Localizations
[Isoform 2]: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.; [Isoform 1]: Cytoplasm. Nucleus matrix. Microsome. Mainly localized in the microsomal fraction and the cytoplasm, and to a lesser extent in the nuclear matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Hepatitis
- Hepatitis B
- Cell Transformation, Neoplastic
- Virus Diseases
- Tumor Angiogenesis
- Pathologic Neovascularization
- Mammary Neoplasms
- Ovarian Neoplasm
- Malignant Neoplasm Of Lung
Interacting Proteins
- DGCR8
- DHX8
- LUC7L
- LUC7L2
- PRPF38A
- RBM39
- RBM8A
- RNPS1
- SAFB
- Safb
Pathways
- Localization
- Protein Phosphorylation
- Cell Cycle
- Nuclear Import
- Rna Splicing
- Mrna Splicing
- Translation
- Mrna Processing
- Transport
- Hyperphosphorylation
- Cell Proliferation
- Drug Resistance
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRPK1
bosterbio.com/bosterbio-gene-info-cards/SRPK1
References
PMID: 8208298 by Gui J.F., et al. A serine kinase regulates intracellular localization of splicing factors in the cell cycle.
PMID: 11509566 by Nikolakaki E., et al. Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B.