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SRSF protein kinase 2 Antibodies
AND SRPK2 ELISA kits, SRSF protein kinase 2 Proteins
Many biological assays use antibodies to detect SRSF protein kinase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRSF protein kinase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRSF protein kinase 2 antibodies...
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SRPK2 Overview
Facts about SRSF protein kinase 2.
SRSF protein kinase 2 (SRPK2)
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in areas full of arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression.
This is carried out by the phosphorylation of SRSF2, causing the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SRPK2 |
| Uniprot: | P78362 |
| Entrez: | 6733 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; FLJ36101; H_RG152G17.1a; H_RG152G17.1b; serine kinase SRPK2; Serine/arginine-rich protein-specific kinase 2; serine/arginine-rich splicing factor kinase 2; serine/threonine-protein kinase SRPK2; SFRS protein kinase 2SFRSK2; SFRSK2; SR protein kinase 2; SRPK2; SR-protein-specific kinase 2; SRSF protein kinase 2; WUGSC:H_RG152G17.1a
Molecular Weight
Mass (kDA):
77.527 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.3 |
| Sequence: | 7; NC_000007.14 (105110708..105399363, complement) |
Tissue Specificity
Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.
Diseases
- Hepatitis
- Hepatitis B
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Neoplasms
- Virus Diseases
- Congenital Cerebellar Hypoplasia
- Myeloid Neoplasm
- Monosomy
- Neoplasm Metastasis
- Brain Ischemia
- Scleroderma
Interacting Proteins
- AES
- ARGLU1
- CLK2
- CLK3
- FXR2
- HNRNPC
- LUC7L
- LUC7L2
- LUZP4
- MMTAG2
Pathways
- Cell Cycle
- Localization
- Protein Phosphorylation
- Cell Proliferation
- Rna Splicing
- Cell Cycle Arrest
- Cell Death
- Transport
- Respiratory Burst
- Nuclear Export
- Dna Replication
- Mrna Splicing
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRPK2
bosterbio.com/bosterbio-gene-info-cards/SRPK2
References
PMID: 9472028 by Wang H.-Y., et al. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
PMID: 12134018 by Daub H., et al. Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.