SPSB4 Antibodies

AND SPSB4 ELISA kits, SPSB4 Proteins

Many biological assays use antibodies to detect SPSB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPSB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPSB4 antibodies...

We validate the specificity of these antibodies to SPSB4 by testing them on tissues known to express SPSB4 positively and negatively. Browse below to find the SPSB4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPSB4 Infographic by Boster Bio

All SPSB4 Products

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Product

Figures

Specificity

Applications

Price

SPSB4 (NM_080862) Human Recombinant Protein

$813
Cat # PROTQ96A44
20 µg

SPSB4 (NM_080862) Human Over-expression Lysate

Human

$628
Cat # LS092369
100 µg

SPSB4 Overview

Facts about SPRY domain-containing SOCS box protein 4.

SPSB4 3D structure. Source: alphafold

SPRY domain-containing SOCS box protein 4 (SPSB4)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. .

Gene Information

Human
Gene Name:	SPSB4
Uniprot:	Q96A44
Entrez:	92369

Family

Belongs to:

SPSB family

Alternative Names

splA/ryanodine receptor domain and SOCS box containing 4; SPRY domain-containing SOCS box protein SSB-4; SSB-4SSB4SPRY domain-containing SOCS box protein 4

Molecular Weight

Mass (kDA):
30.179 kDA

Genomic Context


Human

Location:	3q23
Sequence:	3; NC_000003.12 (141051347..141148611)

Subcellular Localizations

Cytoplasm. Cytoplasm, cytosol. Exhibits a diffuse cytosolic localization.

Interacting Proteins

ELOC

Pathways

Cell Death

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPSB4

References

PMID: 15601820 by Kamura T., et al. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

PMID: 15713673 by Wang D., et al. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.