SPRR2A Antibodies

AND SPRR2A ELISA kits, SPRR2A Proteins

Many biological assays use antibodies to detect SPRR2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPRR2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPRR2A antibodies...

We validate the specificity of these antibodies to SPRR2A by testing them on tissues known to express SPRR2A positively and negatively. Browse below to find the SPRR2A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPRR2A Infographic by Boster Bio

All SPRR2A Products

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Price

SPRR2A (NM_005988) Human Recombinant Protein

$1249
Cat # PROTP35326
20 µg

Anti-SPRR2A Mouse Monoclonal Antibody [Clone ID: OTI4B3]

Human

$523
Cat # M10131
100 µl

SPRR2A (NM_005988) Human Over-expression Lysate

Human

$628
Cat # LS006700
100 µg

SPRR2A Overview

Facts about Small proline-rich protein 2A.

SPRR2A 3D structure. Source: alphafold

Small proline-rich protein 2A (SPRR2A)

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase.

All that results in the formation of an insoluble envelope beneath the plasma membrane. .

Gene Information

Human
Gene Name:	SPRR2A
Uniprot:	P35326
Entrez:	6700

Family

Belongs to:

cornifin (SPRR) family

Alternative Names

2-1; small proline-rich protein 2A; SPR-2A

Molecular Weight

Mass (kDA):
7.965 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (153056120..153057512, complement)

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Malignant Squamous Cell Neoplasm
Dry Eye Syndromes
Carcinoma
Esophageal Neoplasms
Inflammation
Cell Invasion
Metaplasia
Squamous Cell Carcinoma Of Esophagus
Conjunctival Diseases
Asthma
Tissue Adhesions

Corneal Diseases
Disorder Of Eye
Cholangiocarcinoma
Stomach Neoplasms
Neoplasm Metastasis
Keratoconjunctivitis

Interacting Proteins

Pathways

Cell Differentiation
Keratinocyte Differentiation
Epithelial Cell Differentiation
Pathogenesis
Cell Proliferation
Cornification
Keratinization
Cellular Senescence
Immune Response
Neurogenesis
Mammary Gland Development
Metestrus
Sensitization

Translation
Cell Cycle
Estrus
Gastric Acid Secretion
Response To Stress
Gland Development
Proestrus

PTMs

Acetylation
Phosphorylation

Deacetylation
Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPRR2A

References

PMID: 2388825 by Gibbs S., et al. Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.

PMID: 8325635 by Gibbs S., et al. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.