Spondin-2 Antibodies

AND SPON2 ELISA kits, Spondin-2 Proteins

Many biological assays use antibodies to detect Spondin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Spondin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Spondin-2 antibodies...

We validate the specificity of these antibodies to Spondin-2 by testing them on tissues known to express SPON2 positively and negatively. Browse below to find the SPON2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPON2 Infographic by Boster Bio

All SPON2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Spondin-2 SPON2 Antibody

Human, Mouse, Rat

$405
Cat # A07465
100ul

SPON2 (NM_012445) Human Over-expression Lysate

Human

$628
Cat # LS010417
100 µg

Anti-SPON2 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A07465-1
100 µg/vial

SPON2 Overview

Facts about Spondin-2.

SPON2 3D structure. Source: alphafold

Spondin-2 (SPON2)

Cell adhesion protein which promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their parts and functions as an opsonin for macrophage phagocytosis of bacteria.

Critical in the initiation of the innate immune response and represents a special pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Gene Information

Human
Gene Name:	SPON2
Uniprot:	Q9BUD6
Entrez:	10417

Family

Belongs to:

No superfamily

Alternative Names

Differentially expressed in cancerous and non-cancerous lung cells 1; DIL1; DIL-1; DIL1FLJ34460; DKFZp686G21139; FLJ16313; FLJ22401; Mindin; M-SPONDIN; RG-1; SPON2; Spondin 2; spondin 2, extracellular matrix protein; spondin-2

Molecular Weight

Mass (kDA):
35.846 kDA

Genomic Context


Human

Location:	4p16.3
Sequence:	4; NC_000004.12 (1166932..1208962, complement)

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Malignant Neoplasms
Carcinoma
Malignant Neoplasm Of Prostate
Neoplasms
Prostatic Neoplasms
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Diabetic Nephropathy
Tumor Progression
Glaucoma, Open-angle

Neoplasm Invasiveness
Malignant Neoplasm Of Lung
Carcinogenesis
Fibrosis
Tumor Angiogenesis
Aqueous Humor Disorders
Anaplasia

Interacting Proteins

KRT31

Pathways

Methylation
Cell Adhesion
Macrophage Differentiation
Cell Migration
Dedifferentiation
Dna Methylation
Angiogenesis

Wound Healing

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPON2

References

PMID: 10512675 by Manda R., et al. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.

PMID: 19153605 by Li Y., et al. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.