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- Table of Contents
Facts about Serine protease inhibitor Kazal-type 5.
Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Human | |
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Gene Name: | SPINK5 |
Uniprot: | Q9NQ38 |
Entrez: | 11005 |
Belongs to: |
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No superfamily |
Kazal type 5; LEKTI; LETKI; NETS; serine peptidase inhibitor, Kazal type 5; SPINK5; VAKTI
Mass (kDA):
120.714 kDA
Human | |
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Location: | 5q32 |
Sequence: | 5; NC_000005.10 (148063980..148137382) |
Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.
Secreted.
PMID: 10419450 by Maegert H.-J., et al. LEKTI, a novel 15-domain type of human serine proteinase inhibitor.
PMID: 10835624 by Chavanas S., et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.