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LILRB4 Antibodies
AND LILRB4 ELISA kits, LILRB4 Proteins
Many biological assays use antibodies to detect LILRB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LILRB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LILRB4 antibodies...
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LILRB4 Overview
Facts about Leukocyte immunoglobulin-like receptor subfamily B member 4.
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4)
Receptor for class I MHC antigens.
Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.Involved from the down-regulation of the immune response and the development of tolerance, e.g.
Gene Information
| Human | |
|---|---|
| Gene Name: | LILRB4 |
| Uniprot: | Q8NHJ6 |
| Entrez: | 11006 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD85 antigen-like family member K; CD85k antigen; CD85k; HM18; ILT3; ILT-3; ILT3CD85K; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB4; LIR5; LIR5LILRB5; LIR-5subfamily B, member 4; member 4
Molecular Weight
Mass (kDA):
49.356 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.42 |
| Sequence: | 19; NC_000019.10 (54662524..54670359) |
Tissue Specificity
Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Diseases
- Inflammation
- Malignant Neoplasms
- Neoplasms
- Autoimmune Reaction
- Autoimmune Diseases
- Autoimmunity
- Immediate Hypersensitivity
- Edema
- Allergy
- Tissue Adhesions
- Immunologic Deficiency Syndromes
- Anaphylaxis
- Arthritis
Interacting Proteins
- PTPN6
Pathways
- Immune Response
- Cell Activation
- Mast Cell Activation
- Adaptive Immune Response
- Tolerance Induction
- Secretion
- T Cell Activation
- T Cell Proliferation
- Cell Differentiation
- Exocytosis
- Cell Proliferation
- Cell Development
- Chemokine Production
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LILRB4
bosterbio.com/bosterbio-gene-info-cards/LILRB4
References
PMID: 9278324 by Arm J.P., et al. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor.
PMID: 9548455 by Borges L., et al. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.