This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
SPAG5 Antibodies
AND SPAG5 ELISA kits, SPAG5 Proteins
Many biological assays use antibodies to detect SPAG5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPAG5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPAG5 antibodies...
Previous: CCN4
Next: RBCK1
SPAG5 Infographic by Boster Bio
All SPAG5 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A07062-2
100 μg/vial
Cat # A07062-2
100 μg/vial
SPAG5 Overview
Facts about Sperm-associated antigen 5.
Sperm-associated antigen 5 (SPAG5)
Required for chromosome alignment, regular timing of sister chromatid segregation, and maintenance of spindle pole structure (PubMed:17664331, PubMed:27462074). In complicated with SKAP, promotes stable microtubule-kinetochore attachments.
May contribute to the regulation of separase activity. May govern AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792).
Gene Information
| Human | |
|---|---|
| Gene Name: | SPAG5 |
| Uniprot: | Q96R06 |
| Entrez: | 10615 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Astrin; DEEPEST; hMAP126; MAP126mitotic spindle coiled-coil related protein; mitotic spindle associated protein p126; Mitotic spindle-associated protein p126; sperm associated antigen 5; sperm-associated antigen 5
Molecular Weight
Mass (kDA):
134.422 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (28577574..28599025, complement) |
Tissue Specificity
Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Colocalizes with PCM1 at centriolar satellites throughout the cell cycle (PubMed:26297806). In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtu
Diseases
- Dysplasia
- Malignant Neoplasms
- Nervousness
- Sterility
- Hypogonadism
- Neoplasms
- Testicular Dysplasia
- Hypoplasia
- Growth Arrest
- Neoplasm Metastasis
- Infection By Cryptococcus Neoformans
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Liver
Interacting Proteins
- AURKA
- C1orf109
- CDC20B
- CDK5RAP2
- CEP72
- CHCHD3
- CLASP1
- DCX
- EIF4E2
- FBXO28
Pathways
- Mitosis
- Cell Cycle
- Localization
- Cell Death
- Chromosome Segregation
- Metaphase
- Spermatogenesis
- Anaphase
- Prophase
- Spindle Assembly
- Spindle Organization
- Cell Division
- Sister Chromatid Cohesion
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
- Chromatin Research
- Core ESC-Like Genes
- MAP Kinase Signaling
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPAG5
bosterbio.com/bosterbio-gene-info-cards/SPAG5
References
PMID: 11724960 by Mack G.J., et al. Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein.
PMID: 11549262 by Chang M.-S., et al. Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins.