RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1)

Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are essential for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome.

Component of the LUBAC complex which conjugates linear ('Met-1'-connected ) polyubiquitin chains to substrates and plays an integral role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin into IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.