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- Table of Contents
Facts about RanBP-type and C3HC4-type zinc finger-containing protein 1.
Component of the LUBAC complex which conjugates linear ('Met-1'-connected ) polyubiquitin chains to substrates and plays an integral role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin into IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways.
Human | |
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Gene Name: | RBCK1 |
Uniprot: | Q9BYM8 |
Entrez: | 10616 |
Belongs to: |
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RBR family |
C20orf18; EC 6.3.2.-; HBV associated factor 4; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; Hepatitis B virus X-associated protein 4; HOIL-1; RanBP-type and C3HC4-type zinc finger containing 1; ranBP-type and C3HC4-type zinc finger-containing protein 1; RBCC protein interacting with PKC1; RBCK2; RNF54RING finger protein 54; UBCE7IP3HOIL1; ubiquitin conjugating enzyme 7 interacting protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 3; XAP3; XAP4chromosome 20 open reading frame 18; ZRANB4
Mass (kDA):
57.572 kDA
Human | |
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Location: | 20p13 |
Sequence: | 20; NC_000020.11 (408050..432139) |
PMID: 9195957 by Cong Y.-S., et al. The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
PMID: 12629548 by Yamanaka K., et al. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.