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SORBS2 Antibodies
AND SORBS2 ELISA kits, SORBS2 Proteins
Many biological assays use antibodies to detect SORBS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SORBS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SORBS2 antibodies...
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SORBS2 Overview
Facts about Sorbin and SH3 domain-containing protein 2.
Sorbin and SH3 domain-containing protein 2 (SORBS2)
Adapter protein that plays a part in the building of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1.
May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, in addition to dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases sodium and water absorption in the intestine and gall- bladder.
Gene Information
| Human | |
|---|---|
| Gene Name: | SORBS2 |
| Uniprot: | O94875 |
| Entrez: | 8470 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Arg/Abl interacting protein; Arg/Abl-interacting protein 2; ArgBP2; ARGBP2PRO0618; FLJ93447; KIAA0777Arg binding protein 2; sorbin and SH3 domain containing 2; sorbin and SH3 domain-containing protein 2; Sorbin
Molecular Weight
Mass (kDA):
124.108 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q35.1 |
| Sequence: | 4; NC_000004.12 (185585444..185956372, complement) |
Tissue Specificity
Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the pancreas, mainly expressed in acinar cells, duct cells and all cell types in islets (at protein level). Tends to be down-regulated in pancreatic adenocarcinomas ans metastases.
Subcellular Localizations
Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium. Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Pancreatic Neoplasm
- Malignant Neoplasm Of Pancreas
- Neoplasm Invasiveness
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Leukemia
- Neoplasm Metastasis
- Burkitt Lymphoma
- Neoplasms, Radiation-induced
Interacting Proteins
- ACTN4
- ATPAF2
- EFS
- NCK2
- PAK2
- PALLD
- VPS37C
- WAS
- YWHAZ
Pathways
- Localization
- Cell Adhesion
- Cell Migration
- Cell Proliferation
- Senescence
- Translation
PTMs
- Phosphorylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SORBS2
bosterbio.com/bosterbio-gene-info-cards/SORBS2
References
PMID: 9211900 by Wang B., et al. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl- interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.
PMID: 11786189 by Wahbi K., et al. Coding region of the sorbin gene in different species.