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Sohlh1 Antibodies
AND Sohlh1 ELISA kits, Sohlh1 Proteins
Many biological assays use antibodies to detect Sohlh1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sohlh1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sohlh1 antibodies...
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Sohlh1 Overview
Facts about Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1.
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (Sohlh1)
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation (PubMed:22056784).
Coordinates oocyte differentiation without affecting meiosis I (PubMed:28504655). .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Sohlh1 |
| Uniprot: | Q6IUP1 |
| Entrez: | 227631 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bA100C15.3; bHLHe80; C9orf157; NOHLHchromosome 9 open reading frame 157; spermatogenesis and oogenesis specific basic helix-loop-helix 1; spermatogenesis- and oogenesis-specific basic helix-loop-helix-containingprotein 1; TEB2newborn ovary helix loop helix
Molecular Weight
Mass (kDA):
38.188 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2|2 A3 |
| Sequence: | 2; |
Tissue Specificity
In males, it is mainly expressed in testis, while in females it is mainly expressed in ovary. In testis, it is exclusively expressed in spermatogonia, with a preference for prespermatogonia and type A spermatogonia. In ovary, it is detected in germ cell cysts, primordial follicles, and primary follicles but is undetectable by the secondary follicle stage (at protein level). Expressed in the majority of spermatogonia in adult animals, but not in the most undifferentiated spermatogonial population (PubMed:22056784).
Diseases
- Infertility
- Premature Menopause
- Female Infertility
- Amenorrhea
- Testicular Hypogonadism
- Azoospermia
- Tissue Adhesions
- Sterility
Pathways
- Spermatogenesis
- Oogenesis
- Germ Cell Development
- Oocyte Differentiation
- Cell Development
- Meiosis
- Fertilization
- Mitosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sohlh1
bosterbio.com/bosterbio-gene-info-cards/Sohlh1
References
PMID: 16690745 by Pangas S.A., et al. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8.
PMID: 16564520 by Ballow D., et al. Sohlh1 is essential for spermatogonial differentiation.