SNRPE Antibodies

AND SNRPE ELISA kits, SNRPE Proteins

Many biological assays use antibodies to detect SNRPE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SNRPE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SNRPE antibodies...

We validate the specificity of these antibodies to SNRPE by testing them on tissues known to express SNRPE positively and negatively. Browse below to find the SNRPE antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SNRPE Infographic by Boster Bio

All SNRPE Products

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Specificity

Applications

Price

Anti-SNRPE Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A08077
100ul

SNRPE (NM_003094) Human Recombinant Protein

$813
Cat # PROTP62304
20 µg

SNRPE (NM_003094) Human Over-expression Lysate

Human

$628
Cat # LS006635
100 µg

SNRPE Overview

Facts about Small nuclear ribonucleoprotein E.

SNRPE 3D structure. Source: alphafold

Small nuclear ribonucleoprotein E (SNRPE)

Plays role in pre-mRNA splicing as core part of this SMN-Sm complex that mediates spliceosomal snRNP assembly and as part of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Part of the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).

Is also a part of the minor U12 spliceosome (PubMed:15146077). Included in the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).

Gene Information

Human
Gene Name:	SNRPE
Uniprot:	P62304
Entrez:	6635

Family

Belongs to:

snRNP Sm proteins family

Alternative Names

B-raf; Sm protein E; small nuclear ribonucleoprotein E; small nuclear ribonucleoprotein polypeptide E; SmE; Sm-ESME; snRNP-E

Molecular Weight

Mass (kDA):
10.804 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (203861599..203871152)

Tissue Specificity

Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.

Subcellular Localizations

Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Lupus Erythematosus, Systemic
Growth Retardation
Autoimmunity
Ataxia
Hydrocephalus
Infertility
Malignant Neoplasm Of Lung
Carcinogenesis
Nonalcoholic Steatohepatitis

Insulin Resistance
Neoplasms, Hormone-dependent
Hormone Refractory Prostate Cancer
Spinal Muscular Atrophy
Fatty Liver
Malignant Neoplasm Of Prostate
Adenocarcinoma

Interacting Proteins

GEMIN5
GEMIN6
LSM2
SF3A2
SNRPF

SNRPG

Pathways

Pathogenesis
Transport
Cell Proliferation
Mrna Splicing
Translation
S Phase
Cell Growth
Regulation Of Gene Expression

Mrna Transport
Spermatogenesis

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNRPE

References

PMID: 2974536 by Stanford D.R., et al. The complete primary structure of the human snRNP E protein.

PMID: 2972723 by Stanford D.R., et al. The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins.