SNRPD3 Antibodies

AND SNRPD3 ELISA kits, SNRPD3 Proteins

Many biological assays use antibodies to detect SNRPD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SNRPD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SNRPD3 antibodies...

We validate the specificity of these antibodies to SNRPD3 by testing them on tissues known to express SNRPD3 positively and negatively. Browse below to find the SNRPD3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SNRPD3 Infographic by Boster Bio

All SNRPD3 Products

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Product

Figures

Specificity

Applications

Price

Anti-SNRPD3 Antibody

Human

$405
Cat # A09533
100ul

SNRPD3 Human, Small Nuclear Ribonucleoprotein Polypeptide D3 Human Recombinant Protein, Sf9

Human

$250
Cat # PROTP62318
2ug, 10ug, 1mg

SNRPD3 (NM_004175) Human Over-expression Lysate

Human

$628
Cat # LS006634
100 µg

Anti-Sm-D3/SNRPD3 Antibody Picoband®

Human, Mouse, Rat

ELISA, IF, IHC, WB

$370
Cat # A09533-1
100 μg/vial

SNRPD3 Overview

Facts about Small nuclear ribonucleoprotein Sm D3.

SNRPD3 3D structure. Source: alphafold

Small nuclear ribonucleoprotein Sm D3 (SNRPD3)

Plays role in pre-mRNA splicing as core component of this SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of the pre- catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).

Is also a component of the minor U12 spliceosome (PubMed:15146077). Included in the U7 snRNP it's involved in histone pre-mRNA 3'-end processing (By similarity).

Gene Information

Human
Gene Name:	SNRPD3
Uniprot:	P62318
Entrez:	6634

Family

Belongs to:

snRNP core protein family

Alternative Names

small nuclear ribonucleoprotein D3 polypeptide 18kDa; small nuclear ribonucleoprotein Sm D3; snRNP core protein D3

Molecular Weight

Mass (kDA):
13.916 kDA

Genomic Context


Human

Location:	22q11.23
Sequence:	22; NC_000022.11 (24555650..24574971)

Subcellular Localizations

Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Diseases

Lupus Erythematosus, Systemic
Muscular Atrophy
Atrophy
Spinal Muscular Atrophy
Mixed Connective Tissue Disease
Autoimmune Diseases
Connective Tissue Diseases
Autoimmune Reaction
Neoplasms
Epstein-barr Virus Infections
Infectious Mononucleosis
Neurodegenerative Disorders

Dermatomyositis
Polymyositis
Diffuse Scleroderma
Malignant Neoplasms
Sjogren's Syndrome
Colorectal Cancer
Rheumatoid Arthritis

Interacting Proteins

CLNS1A
ERH
LSM7
SNRPB

Pathways

Methylation
Localization
Protein Methylation
Cell Proliferation
Mrna Splicing
Cell Cycle
Mitosis

Nuclear Import

PTMs

Methylation

Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNRPD3

References

PMID: 7527560 by Lehmeier T., et al. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.

PMID: 11747828 by Meister G., et al. Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.