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- Table of Contents
Facts about N-lysine methyltransferase SMYD2.
Shows even greater methyltransferase activity on p53/TP53. Monomethylates'Lys-370' of p53/TP53, resulting in diminished DNA-binding action and subsequent transcriptional regulation action of p53/TP53.
Human | |
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Gene Name: | SMYD2 |
Uniprot: | Q9NRG4 |
Entrez: | 56950 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
EC 2.1.1.43; Histone methyltransferase SMYD2; HSKM-Bzinc finger, MYND domain containing 14; KMT3CEC 2.1.1.-; Lysine N-methyltransferase 3C; MGC119305; SET and MYND domain containing 2; SET and MYND domain-containing protein 2; ZMYND14
Mass (kDA):
49.688 kDA
Human | |
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Location: | 1q32.3 |
Sequence: | 1; NC_000001.11 (214281159..214337136) |
Cytoplasm, cytosol. Nucleus.
PMID: 17108971 by Huang J., et al. Repression of p53 activity by Smyd2-mediated methylation.
PMID: 17242690 by Wang C., et al. C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42.