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- Table of Contents
Facts about E3 ubiquitin-protein ligase SMURF1.
Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404).
Human | |
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Gene Name: | SMURF1 |
Uniprot: | Q9HCE7 |
Entrez: | 57154 |
Belongs to: |
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No superfamily |
E3 ubiquitin ligase SMURF1; EC 6.3.2; EC 6.3.2.-; hSMURF1; KIAA1625; KIAA1625E3 ubiquitin-protein ligase SMURF1; SMAD specific E3 ubiquitin protein ligase 1; SMAD ubiquitination regulatory factor 1; Smad-specific E3 ubiquitin ligase 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMURF1
Mass (kDA):
86.114 kDA
Human | |
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Location: | 7q22.1 |
Sequence: | 7; NC_000007.14 (99027435..99144118, complement) |
Expressed in melanocytes (PubMed:23999003).
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
PMID: 10458166 by Zhu H., et al. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
PMID: 11163210 by Kavsak P., et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.