Junctophilin-2 Antibodies

AND JPH2 ELISA kits, Junctophilin-2 Proteins

Many biological assays use antibodies to detect Junctophilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Junctophilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Junctophilin-2 antibodies...

We validate the specificity of these antibodies to Junctophilin-2 by testing them on tissues known to express JPH2 positively and negatively. Browse below to find the JPH2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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JPH2 Infographic by Boster Bio

All JPH2 Products

Product

Figures

Specificity

Applications

Price

Junctophilin 2 (JPH2) (NM_020433) Human Recombinant Protein

$1249
Cat # PROTQ9BR39
20 µg

Anti-Junctophilin 2 (JPH2) Mouse Monoclonal Antibody [Clone ID: OTI1F5]

Human, Mouse, Rat

IF, WB

$523
Cat # M06785
100 µl

Junctophilin 2 (JPH2) (NM_020433) Human Over-expression Lysate

Human

$960
Cat # LS057158
100 µg

JPH2 Overview

Facts about Junctophilin-2.

JPH2 3D structure. Source: alphafold

Junctophilin-2 (JPH2)

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.

JPH2 is vital for proper intracellular Ca(2+) signaling in cardiac myocytes through its participation in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.

Gene Information

Human
Gene Name:	JPH2
Uniprot:	Q9BR39
Entrez:	57158

Family

Belongs to:

junctophilin family

Alternative Names

JP2; junctophilin 2; junctophilin type 2; junctophilin-2

Molecular Weight

Mass (kDA):
74.222 kDA

Genomic Context


Human

Location:	20q13.12
Sequence:	20; NC_000020.11 (44106590..44187946, complement)

Tissue Specificity

Specifically expressed in skeletal muscle and heart.

Subcellular Localizations

[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.; [Junctophilin-2 N-terminal fragment]: Nucleus. Accumulates in the nucleus of stressed hearts.

Diseases

Hypertrophic Cardiomyopathy
Cardiomyopathies
Hypertrophy
Heart Diseases
Heart Failure
Cardiac Hypertrophy
Cardiac Arrest

Hyperplasia
Cardiomyopathy, Dilated

Pathways

Pathogenesis
Rna Interference

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JPH2

References

PMID: 10891348 by Nishi M., et al. Characterization of human junctophilin subtype genes.

PMID: 20095964 by Woo J.S., et al. S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.