Smoc2 Antibodies

SPARC-related modular calcium-binding protein 2 (Smoc2)

Can stimulate endothelial cell proliferation, migration, in addition to angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness.

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Gene Information

Mouse
Gene Name:	Smoc2
Uniprot:	Q8CD91
Entrez:	64074

Family

Belongs to:
No superfamily

Alternative Names

bA270C4A.1; bA37D8.1; dJ421D16.1; MST117; MSTP117; MSTP140; SMAP2; SMAP-2; SMAP2Secreted modular calcium-binding protein 2; SMOC2; SMOC-2; smooth muscle associated protein 2; Smooth muscle-associated protein 2; SPARC related modular calcium binding 2; SPARC-related modular calcium-binding protein 2; thyroglobulin type-1 repeat containing protein

Molecular Weight

Mass (kDA):
49.891 kDA

Genomic Context

Mouse
Location:	17 A2|17 8.95 cM
Sequence:	17;

Tissue Specificity

Strongly expressed in ovary, followed by heart, muscle, spleen, brain, thymus, lung, liver, kidney, spleen, testis, ovary and skeletal muscle.

Diseases

• Neoplasms
• Tumor Angiogenesis
• Age Related Macular Degeneration
• Malignant Neoplasms
• Generalized Vitiligo
• Cell Invasion
• Adenocarcinoma
• Cell Transformation, Neoplastic
• Tissue Adhesions
• Autoimmune Diseases
• Autoimmune Reaction
• Autoimmunity

• Stillbirth
• Neoplasm Metastasis
• Degenerative Disorder
• Metastatic Malignant Neoplasm To The Lung
• Macule
• Breast Adenocarcinoma
• Thyroid Diseases

Pathways

• Cell Cycle
• Angiogenesis
• Pigmentation
• Transport
• Cell Adhesion
• Cell Proliferation
• Aging
• Dna Methylation
• Endocytosis
• Odontogenesis
• Ossification
• Methylation
• Cartilage Development

• Reverse Transcription
• Translation
• Bone Remodeling
• Cell Growth
• Nucleocytoplasmic Transport
• Mesonephros Development
• Extracellular Matrix Assembly

PTMs

• Disulfide bond

• Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Smoc2

Best Uses Of The SMOC2 Marker

SMOC2 is an high-affinity, modular calcium-binding proteins. This biomarker allows you to identify calcium-binding genes. However, its high affinity nature limits its use in some applications. This article will discuss the best uses for SMOC2 in biomedical and clinical research. You can use this biomarker for your experiments, too.

SMOC2 can be described as a modular calcium-binding proteins

SMOC2 refers to a modular calcium binding Protein, also known SPARC-related. This 55 kDa glycoprotein belongs to the SPARC family of matricellular proteins. This protein's cDNA contains four regions. These include a signal sequence of 21 amino acid, two thyroglobulin like domains and two EF hand sequences. There are three splice variants to SMOC2.

SMOC-2 expression is found in distinct structures during embryogenesis in mouse embryos. Whole mount in situ hybridization shows strong signals in somites, branchial arches, and whole mount. This suggests that SMOC2 is involved in the regulation of cell cycle progression. However, it is not yet clear how it regulates calciumbinding protein. Further research is needed to understand its role in the development process.

SMOC2 has multiple biological functions, including cell growth, cell attachment, tumor development, and growth. Patients with LUAD who have high levels of SMOC1 have poor prognosis. It is also associated in patients with metastatic head, neck, and squamous-cell carcinoma and advanced breast and prostate cancer. These findings are not yet confirmed but it is possible that SMOC2 is involved with tumor development.

This polymorphism found in SMOC2 has been connected to susceptibility towards PACG, but it is not linked to POAG. The genotype GA was significantly higher in patients with PACG than in patients with POAG. There was no difference in SMOC2 genotypes between men and women. These findings are subject to further large-scale investigations. These findings are promising but more research is needed to confirm them.

The SMOC2 genes encode a secreted protein rich in cysteine. It is involved during embryogenesis and regulates extracellular matrix protein expression. It is thought that it plays a role in cell adhesion, integrin-matrix interaction, and glucose metabolism. Although the exact function and role of SMOC-2 is not known in human cells, some studies suggest it to be a molecular trigger that causes angiogenesis.

SMOC2 interacts calcium-dependently with certain proteins. It has been shown that this protein is highly cooperative in binding calcium ions. It also shows cooperation in binding two Ca2+ions to each domain. The interaction between SMOC2 and SCaM was demonstrated in an electrophoretic mobility shift experiment using a DEAE-cellulose column.

It is a high-affinity primary antibody

SMOC2 (55-kDa) is a glycoprotein. It belongs to the SPARC matricellular protein family. It plays a role in ECM organization, growth factor signalling. The mature human protein consists of 425 amino acids and contains one Kazal-like domain and two EF-hand sequences. The protein also contains three splice variants.

This type protein-specific antibodicle shows different stages for affinity maturation. Numerous somatic mutations increase the affinity of the antibody without compromising shape complementarity. The antibody also displays large conformational changes upon engagement with the Hapten. These changes are likely to be caused by the preorganization of paratopes. Preorganization of the paratope increases specificity against the target antibody and reduces cross-reactivity. Affinity maturation seems to select both high binding ability and thermodynamic instability.

SMOC2 was also identified in islets from ICR mice. Pancreatic islet cells were exposed to antibodies against SMOC-1 & SMOC-2 by immunoostaining. A few cells showed strong nuclear staining as well as adjacent connective tissue, blood vessels, and other cells. This study suggests that SMOCs play a key role in preventing the development of pancreatic cancer.

Researchers were able, using NGS, to discover the genetic information for germ line progenitors as well as intermediates in the maturation of antibodies. They used SMOC2 as a model to understand the coevolution of viruses and antibodies. These high affinity binders can improve the host’s immune defense. They are an important tool for immunologists in improving the immune system.

Two evolutionary branches form the PGT121 group. The PGT121 family interacts to a GlycanA on the surface Env proteins. They have different binding site architectures. PGT121 has one side with a closed structure, while SMOC2 and PGT124 are open on the other. This allows the antibodies to reach the surface Env protein and avoid any neighboring glycans.

A similar mechanism can be used to identify mutations in SMOC2 or any other antigen. The process of next-generation sequencing allows reconstruction of antibody clonal lineages, as well as the inference of germ line progenitors. These sequences can be distinguished from the true, unmutated ancestor. It is possible to identify mutations in VL, and VH segments with high confidence. However, the original VLJL and VHDJH junctional sequences are unknown, and insertions and deletions during affinity maturation are also not known.

You can purchase the SMOC2 antibody as a 10 ug or bundle with mIgG Fc BP–HRP. If you are looking to create an ELISA-compatible antigen, you should consider SMOC2 Antibody (F-11) as a good choice. This antibody is suitable for HIV testing. Don't wait!

It is used to identify calcium-binding proteins

SMOC2 is a calcium-binding protein that is secreted from the BM-40 family. It is found to be increased in osteoarthritic articular cartilage. It also has an impact on in-vitro chondrogenesis. It is not known to have any homologs. SMOC2 currently is being studied in an effort to identify a new class calcium-binding proteins that can act as signaling chemicals.

28% of 591 cancers in the CRC were identified as having SMOC2. This gene expression correlated negatively with lymphatic and venous invasion and with tumor stage. It was associated with nuclear b–catenin expression, which was maintained during the adenoma to-carcinoma transition. However, it decreased at the invasive front. SMOC2 expression was not correlated with microsatellite instability, making it a potential prognostic factor.

The SMOC2 genetic code is polymorphic. There are two SNPs that occur in the same part of the genome. Both SNPs occur in the coding region of exon 4, and their effects may influence SMOC2 expression, splicing, and protein properties. The readout of SMOC2 within cells could also be affected by a newly discovered antisense mRNA transcript. Functional analyses may confirm the findings and provide more insight about the roles of these variants.

The study also suggests that SMOC2 may be involved in lung function. Two studies comparing smokers and nonsmokers found that SMOC2 was associated in lower lung function in smokers compared with smokers. These results also suggest that SMOC2 hasoforms can have a different effect on lung function in the presence and absence of smoking. The future study of this gene may help us determine if SMOC2 is involved or not in lung disease and injury.

SMOC2 is an additional cell glycoprotein that contains EF-hand domains for calcium binding and a follistatinlike domain. Studies of SMOC2 suggest that this protein may be involved in several types of diseases, such as primary glaucoma or autoimmune disease. Other studies have implicated SMOC2 with severe developmental defects such as oligodontia.

SMOC2 has not been identified as a pathogenic gene. However the med family does have a complex phenotype. There is a connection between SMOC2 & the MED family, although the genetics are still not clear. One variant in SMOC2 has been identified as a causative mutation. This mutation blocks activation of Wnt and BMP signalling.

SMOC2 has a significant role in the immune response. It plays a vital role in regulating calcium levels. It is not responsible for controlling calcium levels. SMOC2 is also involved in osteoarthritis. This can cause osteoporosis, and glaucoma. Its role in glaucoma research remains unclear.

Mutants in SMOC2 block BMP signalling by mice. The SMOC2 variant will result in mice with shorter femurs or tibias than normal Smoc2+/+ mice. Normal growth plates, however, are available to SMOC2+/+ Mice. BMP can cause SMOC2L359R mice to develop differently than wild-type SMOC2.