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SMC5 Antibodies
AND SMC5 ELISA kits, SMC5 Proteins
Many biological assays use antibodies to detect SMC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMC5 antibodies...
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SMC5 Infographic by Boster Bio
All SMC5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01285
100 μg/vial
Cat # A01285
100 μg/vial
SMC5 Overview
Facts about Structural maintenance of chromosomes protein 5.
Structural maintenance of chromosomes protein 5 (SMC5)
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.
The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is suggested to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMC5 |
| Uniprot: | Q8IY18 |
| Entrez: | 23137 |
Family
| Belongs to: |
|---|
| SMC family |
Alternative Names
hSMC5; KIAA0594SMC5 structural maintenance of chromosomes 5-like 1 (yeast); SMC protein 5; SMC-5; SMC5L1SMC5 structural maintenance of chromosomes 5-like 1; structural maintenance of chromosomes 5; structural maintenance of chromosomes protein 5
Molecular Weight
Mass (kDA):
128.806 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q21.12 |
| Sequence: | 9; NC_000009.12 (70258962..70354873) |
Tissue Specificity
Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).
Subcellular Localizations
Nucleus. Chromosome. Nucleus, PML body. Chromosome, telomere. Associates with chromatin (PubMed:25931565). Colocalizes with SMC6 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
Diseases
- Genomic Instability
- Malignant Neoplasms
- Neoplasms
- Chromosomal Translocation
- Chromosome Breakage
- Genotoxic Stress
- Growth Arrest
- Kabuki Make-up Syndrome
- Cell Invasion
- Cell Transformation, Neoplastic
- Chromosomal Duplication
- Cleft Palate
Interacting Proteins
- SMC6
Pathways
- Dna Repair
- Dna Replication
- Chromosome Segregation
- Mitosis
- Cell Cycle
- Sister Chromatid Cohesion
- Chromosome Condensation
- Recombinational Repair
- Anaphase
- Localization
- Cell Division
- Interphase
- S Phase
PTMs
- Sumoylation
- Phosphorylation
- Cleavage
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMC5
bosterbio.com/bosterbio-gene-info-cards/SMC5
References
PMID: 11408570 by Taylor E.M., et al. Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.
PMID: 16055714 by Potts P.R., et al. Human MMS21/NSE2 is a SUMO ligase required for DNA repair.