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- Table of Contents
Facts about Microtubule-associated serine/threonine-protein kinase 2.
Functions in a multi-protein complicated in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.
Mouse | |
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Gene Name: | Mast2 |
Uniprot: | Q60592 |
Entrez: | 17776 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; EC 2.7.11.1; FLJ39200; KIAA0807RP4-533D7.1; MAST205microtubule associated testis specific serine/threonine protein kinase; microtubule associated serine/threonine kinase 2; microtubule-associated serine/threonine-protein kinase 2; MTSSK
Mass (kDA):
190.534 kDA
Mouse | |
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Location: | 4|4 D1 |
Sequence: | 4; |
Detected in round spermatids and residual bodies but not epididymal spermatozoa (at protein level). Expressed in adult but not fetal testis with levels increasing in parallel with testicular development. Also expressed at high levels in heart, lower levels in all other tissues tested.
PMID: 8246979 by Walden P.D., et al. A novel 205-kDa testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette.
PMID: 8902215 by Walden P.D., et al. Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis.