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- Table of Contents
Facts about Structural maintenance of chromosomes protein 1B.
Contributes to axial element (AE) formation and the organization of chromatin loops across the AE. Plays a crucial role in synapsis, recombination and chromosome movements.
Human | |
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Gene Name: | SMC1B |
Uniprot: | Q8NDV3 |
Entrez: | 27127 |
Belongs to: |
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SMC family |
bK268H5; bK268H5.5; FLJ43748; mitosis-specific chromosome segregation protein like protein beta; SMC protein 1B; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2 (yeast); SMC1 structural maintenance of chromosomes 1-like 2; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L2; structural maintenance of chromosomes 1B; structural maintenance of chromosomes protein 1B
Mass (kDA):
143.908 kDA
Human | |
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Location: | 22q13.31 |
Sequence: | 22; NC_000022.11 (45344063..45413671, complement) |
Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity).
PMID: 14660695 by Cobbe N., et al. The evolution of SMC proteins: phylogenetic analysis and structural implications.