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- Table of Contents
Facts about SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5.
Also needed for replication of pericentric heterochromatin in S-phase especially in combination with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of this SIN3/HDAC1 corepressor complex to the rDNA promoter.
Human | |
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Gene Name: | SMARCA5 |
Uniprot: | O60264 |
Entrez: | 8467 |
Belongs to: |
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SNF2/RAD54 helicase family |
EC 3.6.1; EC 3.6.4.-; hISWI; hSNF2HSWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; ISWI; SMARCA5; SNF2H; SNF2Hsucrose nonfermenting-like 5; subfamily a, member 5; Sucrose nonfermenting protein 2 homolog; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 5; WCRF135
Mass (kDA):
121.905 kDA
Human | |
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Location: | 4q31.21 |
Sequence: | 4; NC_000004.12 (143513501..143557486) |
Ubiquitously expressed.
Nucleus.
PMID: 9730600 by Aihara T., et al. Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI.
PMID: 10880450 by Poot R.A., et al. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.