Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6)

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is vital for the germline integrity. Acts through the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Acts as a co-chaperone through its interaction with HSP90 and is needed for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in elimination of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).