Schlafen family member 11 Antibodies

AND SLFN11 ELISA kits, Schlafen family member 11 Proteins

Many biological assays use antibodies to detect Schlafen family member 11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Schlafen family member 11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Schlafen family member 11 antibodies...

We validate the specificity of these antibodies to Schlafen family member 11 by testing them on tissues known to express SLFN11 positively and negatively. Browse below to find the SLFN11 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLFN11 Infographic by Boster Bio

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Anti-SLFN11 Antibody Picoband®

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A08259
100 μg/vial

SLFN11 Overview

Facts about Schlafen family member 11.

SLFN11 3D structure. Source: alphafold

Schlafen family member 11 (SLFN11)

Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061).

Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at worried replication forks, possibly leading to unwind DNA ahead of the MCM helicase and obstruct fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061).

Gene Information

Human
Gene Name:	SLFN11
Uniprot:	Q7Z7L1
Entrez:	91607

Family

Belongs to:

Schlafen family

Alternative Names

FLJ34922; schlafen family member 11

Molecular Weight

Mass (kDA):
102.836 kDA

Genomic Context


Human

Location:	17q12
Sequence:	17; NC_000017.11 (35350305..35373914, complement)

Tissue Specificity

Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.

Subcellular Localizations

Nucleus. Chromosome. Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061).

Diseases

Malignant Neoplasms
Neoplasms
Cell Invasion
Adenocarcinoma
Fracture Of First Cervical Vertebra
Melanoma
Malignant Paraganglionic Neoplasm
Neoplasm Invasiveness
Immunologic Deficiency Syndromes
Virus Diseases

Retroviridae Infections
Hiv Infections
Innate Immune Response
Malignant Neoplasm Of Ovary
Colorectal Cancer

Pathways

Cell Cycle
Reverse Transcription
Translation
Cell Death
Innate Immune Response
Immune Response

Cell Cycle Arrest

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLFN11

References

PMID: 20956525 by Katsoulidis E., et al. Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells.

PMID: 23000900 by Li M., et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11.