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SLC5A8 Antibodies
AND SLC5A8 ELISA kits, SLC5A8 Proteins
Many biological assays use antibodies to detect SLC5A8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC5A8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC5A8 antibodies...
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SLC5A8 Overview
Facts about Sodium-coupled monocarboxylate transporter 1.
Sodium-coupled monocarboxylate transporter 1 (SLC5A8)
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transportation of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), using a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide.
Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC5A8 |
| Uniprot: | Q8N695 |
| Entrez: | 160728 |
Family
| Belongs to: |
|---|
| sodium:solute symporter (SSF) (TC 2.A.21) family |
Alternative Names
AIT; AITSolute carrier family 5 member 8; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; MGC125354; SLC5A8; SMCT; SMCTSMCT1; Sodium iodide-related cotransporter; sodium-coupled monocarboxylate transporter 1; solute carrier family 5 (iodide transporter), member 8
Molecular Weight
Mass (kDA):
66.578 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q23.1-q23.2 |
| Sequence: | 12; NC_000012.12 (101155493..101210238, complement) |
Tissue Specificity
Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.
Subcellular Localizations
Apical cell membrane; Multi-pass membrane protein. Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Tumor Of Colon
- Colorectal Cancer
- Carcinoma
- Colonic Neoplasms
- Adenoma
- Cell Transformation, Neoplastic
- Carcinogenesis
- Thyroid Neoplasm
- Disease Of Adrenal Medulla
- Carcinoma, Papillary
Pathways
- Transport
- Methylation
- Dna Methylation
- Fermentation
- Localization
- Cell Death
- Glycolysis
- Cell Cycle
- Iodide Transport
- Urate Transport
- Cellular Localization
- Gene Silencing
- Nicotinate Transport
PTMs
- Methylation
- Carboxylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC5A8
bosterbio.com/bosterbio-gene-info-cards/SLC5A8
References
PMID: 12107270 by Rodriguez A.-M., et al. Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.
PMID: 12829793 by Li H., et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers.