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- Table of Contents
Facts about Sodium-coupled neutral amino acid transporter 4.
Has a broad specificity, with a taste for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys.
Human | |
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Gene Name: | SLC38A4 |
Uniprot: | Q969I6 |
Entrez: | 55089 |
Belongs to: |
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amino acid/polyamine transporter 2 family |
Amino acid transporter A3; ATA3MGC126876; FLJ10191; N amino acid transporter 3; Na(+)-coupled neutral amino acid transporter 4; NAT3amino acid transporter system A3; PAAT; SNAT4; sodium-coupled neutral amino acid transporter 4; Solute carrier family 38 member 4; solute carrier family 38, member 4; System A amino acid transporter 3; System N amino acid transporter 3
Mass (kDA):
60.764 kDA
Human | |
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Location: | 12q13.11 |
Sequence: | 12; NC_000012.12 (46764761..46832422, complement) |
Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.
Cell membrane; Multi-pass membrane protein.
PMID: 11342143 by Hatanaka T., et al. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.
PMID: 11414754 by Gu S., et al. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization.