SLC38A1 Antibodies

AND SLC38A1 ELISA kits, SLC38A1 Proteins

Many biological assays use antibodies to detect SLC38A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC38A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC38A1 antibodies...

We validate the specificity of these antibodies to SLC38A1 by testing them on tissues known to express SLC38A1 positively and negatively. Browse below to find the SLC38A1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC38A1 Infographic by Boster Bio

All SLC38A1 Products

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SLC38A1 (NM_001077484) Human Over-expression Lysate

Human

$628
Cat # LS081539
100 µg

SLC38A1 Overview

Facts about Sodium-coupled neutral amino acid transporter 1.

SLC38A1 3D structure. Source: alphafold

Sodium-coupled neutral amino acid transporter 1 (SLC38A1)

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1.

May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May provide glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.

Gene Information

Human
Gene Name:	SLC38A1
Uniprot:	Q9H2H9
Entrez:	81539

Family

Belongs to:

amino acid/polyamine transporter 2 family

Alternative Names

Amino acid transporter A1; ATA1SNAT1; NAT2N-system amino acid transporter 2; SAT1amino acid transporter system A1; sodium-coupled neutral amino acid transporter 1; Solute carrier family 38 member 1; solute carrier family 38, member 1; System A amino acid transporter 1; System N amino acid transporter 1

Molecular Weight

Mass (kDA):
54.048 kDA

Genomic Context


Human

Location:	12q13.11
Sequence:	12; NC_000012.12 (46183063..46269149, complement)

Tissue Specificity

Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity).

Diseases

Glioma
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Fetal Growth Retardation
Neoplasms
Hypoxia
Carcinoma
Acidosis
Inflammation
Carcinogenesis
Nervousness

Malignant Glioma
Brain Neoplasms
Cholangiocarcinoma
Brain Ischemia
Malnutrition
Embryonal Carcinoma
Pregnancy Complications

Interacting Proteins

CD79A
FATE1

Pathways

Transport
Amino Acid Transport
Glutamine Transport
Localization
Sulfation
Signal Transmission
Aging
Gluconeogenesis
Neurogenesis

Neutral Amino Acid Transport
Regeneration
Cholesterol Efflux
Exocytosis

PTMs

Acetylation

Phosphorylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC38A1

References

PMID: 10891391 by Wang H., et al. Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta.

PMID: 12388062 by Nelson D.M., et al. Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts.