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- Table of Contents
Facts about Sodium/potassium/calcium exchanger 5.
Probably transports 1 Ca(2+) and one K(+) into the melanosome in exchange for 4 cytoplasmic Na(+). .
Human | |
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Gene Name: | SLC24A5 |
Uniprot: | Q71RS6 |
Entrez: | 283652 |
Belongs to: |
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Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family |
Sodium/potassium/calcium exchanger 5
Mass (kDA):
54.888 kDA
Human | |
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Location: | 15q21.1 |
Sequence: | 15; NC_000015.10 (48120990..48142672) |
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Enriched in late-stage melanosomes (PubMed:17081065).
PMID: 16357253 by Lamason R.L., et al. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.
PMID: 18166528 by Ginger R.S., et al. SLC24A5 encodes a trans-Golgi network protein with potassium- dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.