SLC11A1 Antibodies

Natural resistance-associated macrophage protein 1 (SLC11A1)

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to specific pathogens. Macrophage-specific membrane transport function.

Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to safeguard the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its own protective enzymes.

Gene Information

Human
Gene Name:	SLC11A1
Uniprot:	P49279
Entrez:	6556

Family

Belongs to:
NRAMP family

Alternative Names

natural resistance-associated macrophage protein 1; LSH; member 1; NRAMP 1; NRAMP1; NRAMP1solute carrier family 11 (sodium/phosphate symporters), member 1; NRAMPnatural resistance-associated macrophage protein 1; SLC11A1; solute carrier family 11 (proton-coupled divalent metal ion transporters)

Molecular Weight

Mass (kDA):
59.872 kDA

Genomic Context

Human
Location:	2q35
Sequence:	2; NC_000002.12 (218381766..218396894)

Tissue Specificity

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

• Tuberculosis
• Salmonella Infections
• Autoimmune Reaction
• Infective Disorder
• Communicable Diseases
• Salmonella Infections, Animal
• Autoimmune Diseases
• Tuberculosis, Pulmonary
• Inflammation
• Bacterial Infections
• Diabetes Mellitus
• Dysequilibrium Syndrome
• Paratuberculosis

• Diabetes Mellitus, Insulin-dependent
• Arthritis
• Leishmaniasis
• Crohn Disease
• Inflammatory Bowel Diseases
• Colitis
• Intestinal Diseases

Pathways

• Transport
• Macrophage Activation
• Pathogenesis
• Immune Response
• Virulence
• Localization
• Inflammatory Response
• Phagocytosis
• Disease Resistance
• Secretion
• Innate Immune Response
• Cell Activation
• Symport

• Sensitization
• Wound Healing
• Glycosylation
• Ion Transport
• Cation Transport
• Rna Interference
• Response To Lipopolysaccharide

PTMs

• Glycosylation
• Phosphorylation

• Biotinylation
• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC11A1

Best Uses And Suppliers Of The SLC11A1 Marker

The SLC11A1 gene plays an important role in the activation of macrophages. It has multiple applications in research. Read this article to learn more about the SLC11A1 Marker and its benefits. It also discusses the applications and suppliers of the SLC11A1 Marker. We hope that you will find this article useful. You can download a free sample of this protein marker and begin your own research.

SLC11A1 gene plays an important role in activating macrophages

The SLC11A1 gene is an essential player in the activation of macrophages. It activates immune cells and induces the expression of various immune modulatory molecules. When MVA-B is present in the body, the expression of MICA molecules is increased. Hence, regulating the SLC11A1 gene is important for macrophage activation.

The SLC11A1 gene encodes NRAMP1, a key component of the innate immune system. It activates macrophages by producing the cytokine TNF-a and IL-6. These cytokines are crucial to the immune response, and mutations in the SLC11A1 gene may increase the severity of RA and autoimmune disease.

In a study of SLC11A1, HDAC7 was found to be essential for the activation of macrophages in response to a toll-like receptor. In contrast, HDAC7-u was found to have no N-terminal 22 amino acids, allowing it to promote LPS-induced activation of HDAC-dependent genes.

SAE has also been shown to induce the production of IL-6 by peritoneal macrophages in mice. These results indicate that SAE may be a beneficial functional food, because it activates macrophages in vivo. Moreover, SAE may also have immunostimulatory effects. These effects could translate to improved health outcomes.

RNF5 and Rap1 are known to affect the expression of SLC11A1. Similarly, RNF5 and pS6-RSV-CREB were found to reduce the expression of mBAFF in mouse macrophages. In addition, RNF5 phosphorylates Epac and inhibits the activity of protein kinase A. The phosphorylation of the RNF5 mRNA on serine 133 was also detected by western blot. Both compounds have a protective role in the activation of macrophages.

Inflammation is promoted by these cells, and they release pro-inflammatory factors. For example, they release IL-6, IL-18, and IL-23, as well as reactive oxygen species and matrix-degrading enzymes. However, despite these benefits, there is no evidence to suggest that this anti-inflammatory drug has any therapeutic value.

The SLC11A1 gene is a key player in the activation of macrophages. It is an important E3 ubiquitin ligase, located in the endoplasmic reticulum, and in the mitochondrial membranes. It plays an important role in various cellular processes, including regulating bacterial and viral infections.

SLC11A1 is a member of the SLC11A1 gene network. It is a member of a gene network that regulates the maturation of DC, cross talk between DC and NK cells, and innate and adaptive immunity. It also functions in antigen presentation and TLR signaling. This gene has important implications for vaccine development.

Suppliers of SLC11A1 Marker

Protein suppliers include government agencies, non-profit organizations, and commercial companies. In the study of Huffman MA and colleagues, libraries of diverse oxidoreductases were obtained from Codexis and Prozomix, respectively. The authors also obtained pore-forming epsilon toxin from the Biodefense and Emerging Infections Research Resources Repository. Suppliers of SLC11A1 Marker include the following organizations:

The SLC11A1 gene encodes a protein that is essential for optimal activation of gd T cells and the expression of IFN-g by innate lymphocytes. In humans, SLC11A1 variants are believed to contribute to pervasive differences between wild-type and SLC11A1-/ mice. A recent study of gd T cells in humans has revealed that SLC11A1 is expressed in more than 80 percent of these cells.

Although SLC11A1 is important in human immune cells, the protein is also expressed in other species, including bovine and sheep. In a recent study, the SLC11A1 gene was linked to the enhanced activation of innate lymphocytes. In bovine and human lymphocytes, cells lacking SLC11A1 did not express IFN-g. The role of SLC11A1 in monocyte activation was studied by using chemical blockade of PTPs.

Applications of SLC11A1 Marker

SLC11A1 is a natural macrophage resistance-associated protein that regulates the activity of macrophages. This marker was recently studied in cattle for its polymorphism in microsatellites in its 3' UTR. Among the seven alleles detected, MS1 and MS2 were identified for the first time, while MS3 was studied for the first time. This research will provide a reference sequence for future experimental design.

To determine the expression level of SLC11A1 in human cells, we have analyzed a panel of genetic markers located around the SLC11A1 gene. The top panel shows the intermarker physical distance; the lower panel indicates the identity of the markers. The short horizontal bars represent PCR fragments. We note that LD6a and LD6b are located on the same fragment and that IL8RA and IL8RB are located in close proximity to one another.

The D543N polymorphism (also known as the 3'UTR) and SLC11A1 showed significant associations with cancer risk. Moreover, this polymorphism is in strong linkage disequilibrium with GTn, 274C/T polymorphism, and TP53A. Therefore, these three markers have been linked to different diseases in the past. However, SLC11A1 polymorphism is more important than ever in cancer research.

Genomic linkage disequilibrium analysis of the SLC11A1 gene in Colombian Creole cattle found a high heterozygosity of microsatellites. According to Carvajal-Carmona et al. (2003), genotype and allele frequencies did not differ significantly, despite the high heterozygosity. The D' and r2 values indicated that there was a linkage disequilibrium between the two microsatellites.