SLC12A4 Antibodies

AND SLC12A4 ELISA kits, SLC12A4 Proteins

Many biological assays use antibodies to detect SLC12A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC12A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC12A4 antibodies...

We validate the specificity of these antibodies to SLC12A4 by testing them on tissues known to express SLC12A4 positively and negatively. Browse below to find the SLC12A4 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC12A4 Infographic by Boster Bio

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SLC12A4 Overview

Facts about Solute carrier family 12 member 4.

SLC12A4 3D structure. Source: alphafold

Solute carrier family 12 member 4 (SLC12A4)

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells.

May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.

Gene Information

Human
Gene Name:	SLC12A4
Uniprot:	Q9UP95
Entrez:	6560

Family

Belongs to:

SLC12A transporter family

Alternative Names

Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; FLJ17069; FLJ40489; hKCC1; KCC1; KCC1erythroid K:Cl cotransporter; K-Cl cotransporter; potassium/chloride cotransporter 1; SLC12A4; solute carrier family 12 (potassium/chloride transporters), member 4; solute carrier family 12 member 4

Molecular Weight

Mass (kDA):
120.65 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (67943474..67968694, complement)

Tissue Specificity

Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Edema
Liver Carcinoma
Hepatitis
Hepatitis C, Chronic
Anemia, Sickle Cell
Tissue Adhesions

Hepatitis C

Pathways

Cell Cycle

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC12A4

References

PMID: 8663127 by Gillen C.M., et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.

PMID: 9516379 by Pellegrino C.M., et al. Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.