Src-like-adapter 2 Antibodies

AND Sla2 ELISA kits, Src-like-adapter 2 Proteins

Many biological assays use antibodies to detect Src-like-adapter 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Src-like-adapter 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Src-like-adapter 2 antibodies...

We validate the specificity of these antibodies to Src-like-adapter 2 by testing them on tissues known to express Sla2 positively and negatively. Browse below to find the Sla2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Sla2 Infographic by Boster Bio

All Sla2 Products

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Specificity

Applications

Price

Anti-Src-like-adapter 2 SLA2 Antibody

Human

$405
Cat # A06566
100ul

SLAP2 (SLA2) (NM_032214) Human Recombinant Protein

$1062
Cat # PROTQ9H6Q3
20 µg

Anti-SLAP2 (SLA2) Mouse Monoclonal Antibody [Clone ID: OTI3A7]

+13

Human

Flow Cytometry, IHC, WB

$523
Cat # M06566
100 µl

Anti-SLAP2 (SLA2) Mouse Monoclonal Antibody [Clone ID: OTI2G3]

Human

Flow Cytometry, IF, IHC, WB

$523
Cat # M06566-1
100 µl

SLAP2 (SLA2) (NM_032214) Human Over-expression Lysate

Human

$628
Cat # LS084174
100 µg

Sla2 Overview

Facts about Src-like-adapter 2.

Src-like-adapter 2 (Sla2)

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells.

May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. .

Gene Information

Mouse
Gene Name:	Sla2
Uniprot:	Q8R4L0
Entrez:	77799

Family

Belongs to:

No superfamily

Alternative Names

C20orf156; FLJ21992; Modulator of antigen receptor signaling; SLAP-2MARS; SLAP2MGC49845; Src-like adapter protein 2; Src-like adapter protein-2; src-like-adapter 2; Src-like-adaptor 2

Molecular Weight

Mass (kDA):
28.476 kDA

Genomic Context


Mouse

Location:	2\|2 H1
Sequence:	2;

Tissue Specificity

Mainly expressed in immune system. Highly expressed in spleen and thymus and expressed at intermediate levels in lung. Not expressed in liver, heart and brain. Isoform 1 is predominant in lung and spleen, while isoform 2 is predominant in thymus.

Diseases

Tissue Adhesions
Huntington Disease
Wiskott-aldrich Syndrome
Infective Disorder
Autoimmunity
Candidiasis
Prion Diseases
Blastomycosis
Neuroblastoma
Infection By Cryptococcus Neoformans
Neurodegenerative Disorders

Crest Syndrome
Alveolar Bone Loss
Parkinson Disease
Disseminated Candidiasis
Udpglucose 4-epimerase Deficiency Disease
Mammary Neoplasms

Pathways

Endocytosis
Localization
Cell Cycle
Cell Adhesion
Transport
Virulence
Clathrin-mediated Endocytosis
Mating
Cell Growth
Cytokinesis
Interphase
Receptor-mediated Endocytosis
Sexual Reproduction

Translation
Membrane Invagination
Cell Cycle Arrest
Mitosis
Conjugation
Actin Nucleation
Secretion

PTMs

Phosphorylation
Myristoylation

Ubiquitination
Acetylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sla2

References

PMID: 12024036 by Loreto M.P., et al. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.

PMID: 11891219 by Pandey A., et al. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.