N-acetyltransferase ESCO1 (Esco1)

Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together.

Compared to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin part SMC3.