SKAP1 Antibodies

AND SKAP1 ELISA kits, SKAP1 Proteins

Many biological assays use antibodies to detect SKAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SKAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SKAP1 antibodies...

We validate the specificity of these antibodies to SKAP1 by testing them on tissues known to express SKAP1 positively and negatively. Browse below to find the SKAP1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SKAP1 Infographic by Boster Bio

All SKAP1 Products

Product

Figures

Specificity

Applications

Price

Anti-SKAP55/SKAP1 Antibody Picoband™

1 Q&As

Human, Rat

IHC, WB

$370
Cat # PB9890
100 μg/vial

Anti-SKAP1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05514
100ul

SKAP55 (SKAP1) (NM_001075099) Human Recombinant Protein

$1249
Cat # PROTQ86WV1
20 µg

SKAP55 (SKAP1) (NM_003726) Human Over-expression Lysate

Human

$628
Cat # LS008631
100 µg

SKAP1 Overview

Facts about Src kinase-associated phosphoprotein 1.

SKAP1 3D structure. Source: alphafold

Src kinase-associated phosphoprotein 1 (SKAP1)

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells.

May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. .

Gene Information

Human
Gene Name:	SKAP1
Uniprot:	Q86WV1
Entrez:	8631

Family

Belongs to:

SKAP family

Alternative Names

SCAP1; SCAP1pp55; SKAP1; SKAP55; SKAP55SKAP-55; src family associated phosphoprotein 1; Src family-associated phosphoprotein 1; src kinase associated phosphoprotein 1; src kinase-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa

Molecular Weight

Mass (kDA):
41.432 kDA

Genomic Context


Human

Location:	17q21.32
Sequence:	17; NC_000017.11 (48133438..48430250, complement)

Tissue Specificity

Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).

Subcellular Localizations

Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

Diseases

Tissue Adhesions
Malignant Neoplasms
Lymphoma
Neoplasms
T-cell Lymphoma
Leukemia
Autoimmunity
Neoplasm Metastasis
Extravasation
Melanoma
Lymphoma, T-cell, Cutaneous
Monocytic Leukemia
Malignant Neoplasm Of Ovary

Chimera Disorder
Mycoses
Cytogenetic Abnormality
Ovarian Neoplasm
Mycosis Fungoides
Cell Invasion
Malignant Neoplasm Of Prostate

Interacting Proteins

BLCAP
FAM102A
FYB1
PRAM1
SH2D4A

Pathways

Conjugation
Cell Activation
T Cell Activation
Cytokine Production
Cell Motility
Lymphocyte Activation
Cell Adhesion
Cell Proliferation
Localization
Integrin Activation
Hyperphosphorylation
Regulation Of Signaling
Mitosis

Proteolysis
Metaphase
Chromosome Segregation
Anaphase
Cell Death
T Cell Proliferation
Spindle Assembly Checkpoint

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SKAP1

References

PMID: 9195899 by Marie-Cardine A., et al. Molecular cloning of SKAP55, a novel protein that associates with p59fyn in human T-lymphocytes.

PMID: 9748251 by Marie-Cardine A., et al. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.