SIGLEC12 Antibodies

AND SIGLEC12 ELISA kits, SIGLEC12 Proteins

Many biological assays use antibodies to detect SIGLEC12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIGLEC12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIGLEC12 antibodies...

We validate the specificity of these antibodies to SIGLEC12 by testing them on tissues known to express SIGLEC12 positively and negatively. Browse below to find the SIGLEC12 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIGLEC12 Infographic by Boster Bio

All SIGLEC12 Products

Product

Figures

Specificity

Applications

Price

Anti-SIGLEC12 Antibody

Mouse

$405
Cat # A10550
100ul

SIGLECL1 (SIGLEC12) (NM_053003) Human Over-expression Lysate

Human

$628
Cat # LS089858
100 µg

Anti-SIGLEC12 Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A10550-1
100 μg/vial

SIGLEC12 Overview

Facts about Sialic acid-binding Ig-like lectin 12.

SIGLEC12 3D structure. Source: alphafold

Sialic acid-binding Ig-like lectin 12 (SIGLEC12)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Information

Human
Gene Name:	SIGLEC12
Uniprot:	Q96PQ1
Entrez:	89858

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

FLJ38600; S2V; sialic acid binding Ig-like lectin 12; sialic acid-binding Ig-like lectin 12; Siglec-12; SIGLECL1; SIGLECL1Sialic acid-binding Ig-like lectin-like 1; SIGLEC-like 1; Siglec-XII; SLG; SLGSiglec-L1

Molecular Weight

Mass (kDA):
64.984 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51491227..51501800, complement)

Tissue Specificity

Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Malignant Neoplasms
Leukemia
Lymphoma
Lymphoid Leukemia
Chronic Lymphocytic Leukemia

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
Carcinoma

Pathways

Localization

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGLEC12

References

PMID: 11409877 by Foussias G., et al. Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs.

PMID: 11546777 by Angata T., et al. A second uniquely human mutation affecting sialic acid biology.