SIGLEC11 Antibodies

AND SIGLEC11 ELISA kits, SIGLEC11 Proteins

Many biological assays use antibodies to detect SIGLEC11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIGLEC11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIGLEC11 antibodies...

We validate the specificity of these antibodies to SIGLEC11 by testing them on tissues known to express SIGLEC11 positively and negatively. Browse below to find the SIGLEC11 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIGLEC11 Infographic by Boster Bio

All SIGLEC11 Products

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Product

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Specificity

Applications

Price

Anti-Siglec11 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A12601
0.1 mg

SIGLEC11 (NM_052884) Human Over-expression Lysate

Human

$960
Cat # LS114132
100 µg

SIGLEC11 Overview

Facts about Sialic acid-binding Ig-like lectin 11.

SIGLEC11 3D structure. Source: alphafold

Sialic acid-binding Ig-like lectin 11 (SIGLEC11)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid.

The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. From the immune response, may serve as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Gene Information

Human
Gene Name:	SIGLEC11
Uniprot:	Q96RL6
Entrez:	114132

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

sialic acid binding Ig-like lectin 11; sialic acid-binding Ig-like lectin 11; Sialic acid-binding lectin 11; Siglec11; Siglec-11

Molecular Weight

Mass (kDA):
75.795 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (49948825..49961172, complement)

Tissue Specificity

Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Tissue Adhesions
Stomach Neoplasms
Gliosis
Nerve Degeneration
Helicobacter Infections
Neurotoxicity Syndromes
Pre-eclampsia
Gastritis
Carcinoma
Polycystic Ovary Syndrome
Ulcer
Helicobacter Pylori Infection

Malignant Neoplasm Of Stomach
Idiopathic Erosive/hemorrhagic Gastritis
Peptic Ulcer
Neoplasms
Nervousness
Encephalitis
Gastric Erosions

Pathways

Gene Conversion
Transport
Cell Adhesion
Phagocytosis
Ion Transport
Ovulation

Secretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIGLEC11

References

PMID: 11986327 by Angata T., et al. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.