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SH2D1A Antibodies
AND SH2D1A ELISA kits, SH2D1A Proteins
Many biological assays use antibodies to detect SH2D1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SH2D1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SH2D1A antibodies...
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SH2D1A Overview
Facts about SH2 domain-containing protein 1A.
SH2 domain-containing protein 1A (SH2D1A)
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family like SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.
Initially it's been suggested that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors such as INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). But, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214).
Gene Information
| Human | |
|---|---|
| Gene Name: | SH2D1A |
| Uniprot: | O60880 |
| Entrez: | 4068 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DSHP; DSHPLYP; Duncan disease SH2-protein; EBVS; FLJ92177; IMD5; LYP; MTCP1; SAP/SH2D1A; SAPlymphoproliferative syndrome; SH2 domain containing 1A; SH2 domain-containing protein 1A; SH2D1A; signaling lymphocyte activation molecule-associated protein; Signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; XLP; XLPD; XLPDFLJ18687; XLPSH2 domain protein 1A
Molecular Weight
Mass (kDA):
14.187 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq25 |
| Sequence: | X; NC_000023.11 (124346282..124373160) |
Tissue Specificity
Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
Subcellular Localizations
Cytoplasm.
Diseases
- Lymphoproliferative Disorders
- X-linked Lymphoproliferative Disorders
- Epstein-barr Virus Infections
- Immunologic Deficiency Syndromes
- Lymphoma
- Infectious Mononucleosis
- Lymphohistiocytosis, Hemophagocytic
- Virus Diseases
- Infective Disorder
- Hypogammaglobulinemia
- Primary Immune Deficiency Disorder
- Autoimmune Reaction
Interacting Proteins
- ARHGEF6
- ARHGEF7
- CD244
- CD247
- LHX4
- MET
- SLAMF1
- SLAMF6
- TNK2
Pathways
- Lymphocyte Activation
- Cell Activation
- Pathogenesis
- Immune Response
- Cytokine Production
- T Cell Activation
- Secretion
- Cell Development
- Cell Proliferation
- Cell Differentiation
- Germinal Center Formation
- Cytokine Secretion
- T Cell Proliferation
PTMs
- Phosphorylation
- Methylation
Research Areas
- Immune System Diseases
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH2D1A
bosterbio.com/bosterbio-gene-info-cards/SH2D1A
References
PMID: 9771704 by Coffey A.J., et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene.
PMID: 9774102 by Sayos J., et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.