SETDB2 Antibodies

AND SETDB2 ELISA kits, SETDB2 Proteins

Many biological assays use antibodies to detect SETDB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SETDB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SETDB2 antibodies...

We validate the specificity of these antibodies to SETDB2 by testing them on tissues known to express SETDB2 positively and negatively. Browse below to find the SETDB2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SETDB2 Infographic by Boster Bio

All SETDB2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Setdb2 Antibody

5 Q&As

Human, Mouse

ELISA, WB

$629
Cat # A08290
100ug

Anti-CLLD8/SETDB2 Picoband® Antibody

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # A08290-2
100 μg/vial

Anti-CLLD8/Setdb2 Antibody Picoband®

Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A08290-3
100 μg/vial

SETDB2 Overview

Facts about Histone-lysine N-methyltransferase SETDB2.

SETDB2 3D structure. Source: alphafold

Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Especially trimethylates'Lys-9' of histone H3 (H3K9me3).

H3K9me3 is a particular tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats.

Gene Information

Human
Gene Name:	SETDB2
Uniprot:	Q96T68
Entrez:	83852

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

C13orf4; chromosome 13 open reading frame 4; chronic lymphocytic leukemia deletion region 8; Chronic lymphocytic leukemia deletion region gene 8 protein; CLLD8DKFZp761J1217; DKFZp586I0123; EC 2.1.1.43; histone-lysine N-methyltransferase SETDB2; KMT1FCLLL8; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SET domain, bifurcated 2

Molecular Weight

Mass (kDA):
81.894 kDA

Genomic Context


Human

Location:	13q14.2
Sequence:	13; NC_000013.11 (49444274..49495003)

Tissue Specificity

Ubiquitous. Highest expression in heart, testis and ovary.

Subcellular Localizations

Nucleus. Chromosome.

Diseases

Asthma
Rhinorrhea
Dermatitis
Rett Syndrome
Dermatitis, Atopic
Developmental Delay (disorder)
Childhood Asthma
Carcinogenesis
Epilepsy
Childhood Atopic Dermatitis
Allergic Rhinitis (disorder)
Autistic Disorder

Leukemia
Cytogenetic Abnormality
Lymphoid Leukemia
Chronic Lymphocytic Leukemia
Autism Spectrum Disorders
Dysequilibrium Syndrome
Metabolic Bone Disorder

Interacting Proteins

ARL14EP

Pathways

Methylation
Mitosis
Viral Transcription
Sister Chromatid Cohesion
Cell Differentiation
Chromosome Condensation
Chromosome Segregation
Meiosis

Oogenesis
Chromatin Remodeling

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SETDB2

References

PMID: 11306461 by Mabuchi H., et al. Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.

PMID: 20404330 by Falandry C., et al. CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation.