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- Table of Contents
Facts about N-lysine methyltransferase SETD6.
Protein-lysine N-methyltransferase.
Monomethylates'Lys- 310' of the RELA subunit of NF-kappa-B complex, resulting in down- regulate NF-kappa-B transcription factor action.Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (PubMed:23324626).
Mouse | |
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Gene Name: | Setd6 |
Uniprot: | Q9CWY3 |
Entrez: | 66083 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
SET domain containing 6; SET domain-containing protein 6
Mass (kDA):
52.96 kDA
Mouse | |
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Location: | 8|8 D1 |
Sequence: | 8; |
PMID: 23324626 by Binda O., et al. SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.