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Alpha-1-antichymotrypsin Antibodies
AND SERPINA3 ELISA kits, Alpha-1-antichymotrypsin Proteins
Many biological assays use antibodies to detect Alpha-1-antichymotrypsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-1-antichymotrypsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-1-antichymotrypsin antibodies...
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SERPINA3 Infographic by Boster Bio
All SERPINA3 Products
Product
Figures
Specificity
Applications
Price
Human
IP, IF, IHC, ICC, WB
$370
Cat # M02312
100 μl
Cat # M02312
100 μl
Human, Mouse, Rat
IF, IHC, WB
$405
Cat # A02312-1
100ul
Cat # A02312-1
100ul
SDS-PAGE
$243
Cat # PROTP01011
Starting from 20ug
Cat # PROTP01011
Starting from 20ug
Human
$628
Cat # LS000012
100 µg
Cat # LS000012
100 µg
SERPINA3 Overview
Facts about Alpha-1-antichymotrypsin.
Alpha-1-antichymotrypsin (SERPINA3)
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SERPINA3 |
| Uniprot: | P01011 |
| Entrez: | 12 |
Family
| Belongs to: |
|---|
| serpin family |
Alternative Names
AACTMGC88254; ACTGIG25; alpha 1-Antichymotrypsin; alpha-1-antichymotrypsin; antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; growth-inhibiting protein 24; growth-inhibiting protein 25; member 3; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A, member 3; Serpin A3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
Molecular Weight
Mass (kDA):
47.651 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.13 |
| Sequence: | 14; NC_000014.9 (94612391..94624053) |
Tissue Specificity
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Inflammation
- Hemorrhage
- Alzheimer's Disease
- Neoplasms
- Aneurysm
- Subarachnoid Hemorrhage
- Hypertensive Disease
- Intracranial Aneurysm
- Fetal Growth Retardation
- Pre-eclampsia
- Chronic Obstructive Airway Disease
- Hemorrhage, Aneurysmal Subarachnoid
Interacting Proteins
- DNAJC1
Pathways
- Localization
- Cell Adhesion
- Coagulation
- Pathogenesis
- Immune Response
- Proteolysis
- Inflammatory Response
- Ovulation
- Cellular Localization
- Secretion
- Aging
- Protein Secretion
- Oxidative Phosphorylation
PTMs
- Cleavage
- Methylation
- Phosphorylation
Research Areas
- Breast Cancer
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINA3
bosterbio.com/bosterbio-gene-info-cards/SERPINA3
References
PMID: 6606438 by Chandra T., et al. Sequence homology between human alpha 1-antichymotrypsin, alpha 1- antitrypsin, and antithrombin III.
PMID: 8244391 by Poller W., et al. A leucine-to-proline substitution causes a defective alpha 1- antichymotrypsin allele associated with familial obstructive lung disease.