Sentrin-specific protease 2 (SENP2)

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins.

The second is that the deconjugation of SUMO1, SUMO2 and SUMO3 from proteins that are targeted, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 amounts and thereby modulate the Wnt pathway.