SEC63 Antibodies

AND SEC63 ELISA kits, SEC63 Proteins

Many biological assays use antibodies to detect SEC63, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SEC63 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SEC63 antibodies...

We validate the specificity of these antibodies to SEC63 by testing them on tissues known to express SEC63 positively and negatively. Browse below to find the SEC63 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SEC63 Infographic by Boster Bio

All SEC63 Products

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SEC63 (NM_007214) Human Recombinant Protein

$1062
Cat # PROTQ9UGP8
20 µg

SEC63 (NM_007214) Human Over-expression Lysate

Human

$628
Cat # LS011231
100 µg

SEC63 Overview

Facts about Translocation protein SEC63 homolog.

SEC63 3D structure. Source: alphafold

Translocation protein SEC63 homolog (SEC63)

Mediates cotranslational and post-translational transport of specific precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with brief and apolar signal peptides.

May collaborate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins to the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation into the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the principal cilia (By similarity).

Gene Information

Human
Gene Name:	SEC63
Uniprot:	Q9UGP8
Entrez:	11231

Family

Belongs to:

No superfamily

Alternative Names

PRO2507; SEC63 homolog (S. cerevisiae); SEC63LERdj2; SEC63-like (S. cerevisiae); translocation protein SEC63 homolog

Molecular Weight

Mass (kDA):
87.997 kDA

Genomic Context


Human

Location:	6q21
Sequence:	6; NC_000006.12 (107867756..107958208, complement)

Tissue Specificity

Widely expressed, with high levels in the liver.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Liver Diseases
Polycystic Liver Disease
Neoplasms
Malignant Neoplasms
Microsatellite Instability
Polycystic Kidney, Autosomal Dominant
Polycystic Kidney Diseases
Kidney Diseases
Mutation, Out-of-frame
Germline Mutation Abnormality
Physiological Stress
Colorectal Neoplasms

Colorectal Cancer
Malignant Neoplasm Of Stomach
Cystic Disease -retired-
Stomach Neoplasms
Hepatic Cyst
Fenestration (morphologic Abnormality)
Carcinogenesis

Interacting Proteins

Pathways

Transport
Protein Transport
Localization
Secretory Pathway
Glycosylation
Cell Growth
Protein Import
Mating
Membrane Fusion
Protein Folding
Secretion
Protein Processing
Protein Secretion

Cell Division
Reverse Transcription
Karyogamy
Cell Cycle
Nuclear Membrane Fusion
Cell Death
Signal Peptide Processing

PTMs

Glycosylation
Ubiquitination
Phosphorylation

Cleavage
Methylation
Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEC63

References

PMID: 10543453 by Skowronek M.H., et al. Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.

PMID: 10799540 by Meyer H.-A., et al. Mammalian Sec61 is associated with Sec62 and Sec63.