POLG2 Antibodies

AND POLG2 ELISA kits, POLG2 Proteins

Many biological assays use antibodies to detect POLG2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLG2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLG2 antibodies...

We validate the specificity of these antibodies to POLG2 by testing them on tissues known to express POLG2 positively and negatively. Browse below to find the POLG2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POLG2 Infographic by Boster Bio

All POLG2 Products

Product

Figures

Specificity

Applications

Price

Anti-POLG2 Antibody

3 Q&As

Human, Mouse

IHC

$360
Cat # A06012
100 µl

POLG2 (NM_007215) Human Over-expression Lysate

Human

$628
Cat # LS011232
100 µg

POLG2 Overview

Facts about DNA polymerase subunit gamma-2, mitochondrial.

POLG2 3D structure. Source: alphafold

DNA polymerase subunit gamma-2, mitochondrial (POLG2)

Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme.

Binds to ss-DNA. .

Gene Information

Human
Gene Name:	POLG2
Uniprot:	Q9UHN1
Entrez:	11232

Family

Belongs to:

No superfamily

Alternative Names

DNA polymerase gamma accessory 55 kDa subunit; DNA polymerase subunit gamma-2, mitochondrial; EC 2.7.7.7; HP55; Mitochondrial DNA polymerase accessory subunit; mitochondrial DNA polymerase subunit gamma-2; mitochondrial DNA polymerase, accessory subunit; MtPolB; MTPOLBPOLG-BETA; p55; PEOA4; POLB; POLGB; PolG-beta; polymerase (DNA directed), gamma 2, accessory subunit

Molecular Weight

Mass (kDA):
54.911 kDA

Genomic Context


Human

Location:	17q23.3
Sequence:	17; NC_000017.11 (64477785..64497054, complement)

Subcellular Localizations

Mitochondrion.

Diseases

Chronic Progressive External Ophthalmoplegia
Mitochondrial Diseases
External Ophthalmoplegia
Ophthalmoplegia
Myopathy
Malignant Neoplasms
Diffuse Cerebral Sclerosis Of Schilder
Mitochondrial Neurogastrointestinal Encephalopathy Syndrome
Epilepsy
Mitochondrial Dna Depletion
Malignant Neoplasm Of Urinary Bladder
Neoplasms

Atrophy
Diabetes Mellitus
Dysarthria
Blepharoptosis
Dysmyelopoietic Syndromes
Bladder Neoplasm
Lung Neoplasms

Interacting Proteins

POLG

Pathways

Oxidative Phosphorylation
Dna Replication
Embryo Development
Mitochondrial Dna Replication
Transport
Dna Repair
Pathogenesis
Electron Transport
Electron Transport Chain
Fertilization
Oocyte Growth
Regulation Of Gene Expression
Metaphase

Insemination
Blastocyst Formation
Mismatch Repair
Anatomical Structure Development
System Development
Metabolic Process
Blastocyst Development

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLG2

References

PMID: 10608893 by Lim S.E., et al. The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance.

PMID: 10666468 by Carrodeguas J.A., et al. Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase.