Syntenin-1 Antibodies

Syntenin-1 (SDCBP)

Multifunctional adapter protein involved in diverse array of functions such as trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1- mediated SMAD2/3 activation and TGFB1-induced epithelial-to- mesenchymal transition (EMT) and cell migration in various cell types.

May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and following CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).

Gene Information

Human
Gene Name:	SDCBP
Uniprot:	O00560
Entrez:	6386

Family

Belongs to:
No superfamily

Alternative Names

MDA9; MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; ST1; SYCLTACIP18; syndecan binding protein (syntenin); Syndecan-binding protein 1; syntenin-1

Molecular Weight

Mass (kDA):
32.444 kDA

Genomic Context

Human
Location:	8q12.1
Sequence:	8; NC_000008.11 (58552924..58582860)

Tissue Specificity

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Subcellular Localizations

Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, extracellular exosome. Membrane raft. Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and pho

Diseases

• Malignant Neoplasms
• Neoplasm Metastasis
• Neoplasms
• Tissue Adhesions
• Melanoma
• Cell Invasion
• Malignant Neoplasm Of Breast
• Neoplasm Invasiveness
• Nervousness
• Malignant Neoplasm Of Stomach
• Swine Diseases
• Neurofibromatoses

• Neurofibromatosis 2
• Salmonella Infections
• Salmonella Infections, Animal
• Stomach Neoplasms
• Metastatic Malignant Neoplasm To The Lymph Node
• Muscular Fasciculation
• Malignant Tumor Of Colon

Pathways

• Localization
• Cell Adhesion
• Cell Migration
• Synaptic Transmission
• Transport
• Cell Motility
• Cell Growth
• Pathogenesis
• Membrane Organization
• Proteolysis
• Regulation Of Axon Extension
• Virulence
• Cell Division

• Axon Extension
• Reverse Transcription
• Translation
• Exocytosis
• Secretory Pathway
• Intracellular Transport
• Vesicle Transport

PTMs

• Phosphorylation
• Ubiquitination

• Biotinylation
• Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SDCBP

Best Uses Of The SDCBP Marker From Boster Bio

You have found the right website if are looking to find an Anti-Syntenin DCP marker. We have provided you with an some information about the Boster Bio product and its use in Clinical Studies. Check out the following article for more details about its Clinical Applications and Safety. To conduct experiments using immunofluorescence you can also make use of the Anti-Syntenin SDBP Marker.

Boster Bio Anti-Syntenin SDCBP Marker

Boster Bio Anti-Syntenine SDCBP marker uses Human as its primary target. This antibody has been validated by comparing positive and negative samples. It is available in all countries. It is kept at -20°C for up to a year and at temperatures of 4 degrees Celsius for up to a month. The Boster Bio Antibody has been validated to be used in all research laboratories around the world, including those from academia as well as the pharmaceutical, biomedical, and the forensic field.

Clinical applications

The SDCBP marker is used in various cancer diagnostic procedures. The protein binds to syndecans, which are transmembrane protein that contains glycosaminoglycan chains. They are involved in a variety of cell processes and are dysregulated in a wide range of human cancers. The SDCBP cytoplasmic region is enriched in tumor tissues. In a recent study this protein was shown to be associated with malignant status of the glioma.