Protein scribble homolog Antibodies

Protein scribble homolog (SCRIB)

Scaffold protein involved in various areas of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most likely functions in the creation of apico-basal cell polarity.

May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for example through acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling.

Gene Information

Human
Gene Name:	SCRIB
Uniprot:	Q14160
Entrez:	23513

Family

Belongs to:
LAP (LRR and PDZ) protein family

Alternative Names

protein scribble homolog; CRIB1; SCRB1; SCRIB1; scribbled homolog (Drosophila); Vartul

Molecular Weight

Mass (kDA):
174.885 kDA

Genomic Context

Human
Location:	8q24.3
Sequence:	8; NC_000008.11 (143790925..143815773, complement)

Tissue Specificity

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity.

Diseases

• Neoplasms
• Malignant Neoplasms
• Cell Transformation, Neoplastic
• Tissue Adhesions
• Cell Invasion
• Mammary Neoplasms
• Malignant Paraganglionic Neoplasm
• Tumor Progression
• Malignant Neoplasm Of Breast
• Carcinoma
• Neoplasm Metastasis
• Common Wart

• Metaplastic Cell Transformation
• Carcinogenesis
• Adenocarcinoma
• Papillomavirus Infections
• Neoplasm Invasiveness
• Nervousness
• Dysplasia

Interacting Proteins

• ADAM22
• ADRA1D
• APC
• ARHGEF7
• ATP2B1

• ATP2B2
• CRHR1
• CTNND2
• CYSLTR2
• DNM1L

• FAM163B
• FASTKD5
• FRMPD4
• GUCY1A2
• KCNA5

• KCNJ12
• KCNJ4
• MAPK12
• MAPK3
• MCC

• NET1
• NXPE2
• PHLPP1
• PKP4
• RALBP1

• RPS6KA1
• RPS6KA2
• SLC15A5
• SLC6A12
• TANC1

• TSHR
• VEPH1
• WTIP
• WWTR1
• YAP1

Pathways

• Localization
• Cell Proliferation
• Cell Migration
• Cell Growth
• Cell Adhesion
• Cell Division
• Cell-cell Adhesion
• Neural Tube Closure
• Tube Closure
• Cell Cycle
• Wound Healing
• Cell Death
• Receptor Recycling

• Exocytosis
• Oogenesis
• Protein Targeting
• Cell Motility
• Cell Differentiation
• Establishment Of Cell Polarity
• Immune Response

PTMs

• Phosphorylation
• Ubiquitination

• Cleavage
• Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCRIB

Best Uses Of The SCRIB Marker

In this article, we will explain the benefits of the SCRIB Marker, its history and optimization tips. We will also touch on Steven Boster's bio. Scientists around the globe use this revolutionary device to conduct a variety tests. It is perfect for basic and advanced testing because of its versatility and user-friendly. It is compatible with numerous software applications, including Microsoft Excel.

Benefits of using the SCRIB Marker

The SCRIB marker can be used to mark nearly any kind of substance. This is among its biggest advantages. These markers can mark plastic, hardened steel as well as 60-HRC steel. The SCRIB is typically used in automotive production lines. It makes it easy to write a legible car identification numbers. It can also be utilized in other industries, for different reasons. The SCRIB marker is available with a variety of stylus to use.

The SCRIB marker is a wonderful tool to mark surfaces with precise lines. The machine employs a carbide and diamond tip to create permanent indentation marks on substrate materials. The SCRIB Marker is also effective at marking curved and oval surfaces. It is fast and produces an accurate line. It is simple to use and creates a uniform line.

Steven Boster's history

If you're looking to know more about Steven Boster's background The first product he created was created in 1993. It was known as "he who converts science in the lavatory." He created a variety of primary antibodies , and later, various IHC products. In the late 90s, his company had grown into the largest catalog antibody business in China. PicoKine(tm) is a proprietary ELISA platform, was invented by him. He then began to create high-sensitivity ELISA kit designs.