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- Table of Contents
Facts about Zinc transporter ZIP14.
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Human | |
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Gene Name: | SLC39A14 |
Uniprot: | Q15043 |
Entrez: | 23516 |
Belongs to: |
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ZIP transporter (TC 2.A.5) family |
Irt-like protein 14; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; solute carrier family 39 (metal ion transporter), member 14; solute carrier family 39 (zinc transporter), member 14; solute carrier family 39 member 14; zinc transporter ZIP14; ZIP14; ZIP-14; zrt- and Irt-like protein 14
Mass (kDA):
54.212 kDA
Human | |
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Location: | 8p21.3 |
Sequence: | 8; NC_000008.11 (22367278..22434129) |
Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Isoform 1 is ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:15642354, PubMed:7584044, PubMed:27231142). Isoform 3 is widely expressed but not detected in brain, heart, skeletal muscle and fetal skin (PubMed:27231142).
Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, lamellipodium. Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
PMID: 12659941 by Taylor K.M., et al. The LZT proteins; the LIV-1 subfamily of zinc transporters.
PMID: 15642354 by Taylor K.M., et al. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.