This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
SCN9A Antibodies
AND SCN9A ELISA kits, SCN9A Proteins
Many biological assays use antibodies to detect SCN9A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN9A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN9A antibodies...
Previous: CBLIF
Next: SCN10A
SCN9A Infographic by Boster Bio
All SCN9A Products
Product
Figures
Specificity
Applications
Price
SCN9A Overview
Facts about Sodium channel protein type 9 subunit alpha.
Sodium channel protein type 9 subunit alpha (SCN9A)
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784).
It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
Gene Information
| Human | |
|---|---|
| Gene Name: | SCN9A |
| Uniprot: | Q15858 |
| Entrez: | 6335 |
Family
| Belongs to: |
|---|
| sodium channel (TC 1.A.1.10) family |
Alternative Names
ETHA; FEB3B; NE-NA; NENAVoltage-gated sodium channel subunit alpha Nav1.7; Neuroendocrine sodium channel; Peripheral sodium channel 1; PN1hNE-Na; sodium channel protein type 9 subunit alpha; Sodium channel protein type IX subunit alpha; sodium channel, voltage-gated, type IX, alpha subunit; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated, type IX, alpha polypeptide
Molecular Weight
Mass (kDA):
226.372 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.3 |
| Sequence: | 2; NC_000002.12 (166195185..166375987, complement) |
Tissue Specificity
Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection. In neurite terminals.
Diseases
- Pain
- Erythromelalgia
- Neuralgia
- Pain Syndrome
- Channelopathies
- Primary Erythromelalgia
- Congenital Pain Insensitivity
- Chronic Pain
- Burning Pain
- Nervousness
- Malignant Neoplasms
Pathways
- Hypersensitivity
- Localization
- Innervation
- Reflex
- Pathogenesis
- Sensitization
- Cell Proliferation
- Endocytosis
- Defecation
- Transport
- Cell Migration
- Neurogenesis
- Oxidative Phosphorylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN9A
bosterbio.com/bosterbio-gene-info-cards/SCN9A
References
PMID: 7720699 by Klugbauer N., et al. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.
PMID: 17167479 by Cox J.J., et al. An SCN9A channelopathy causes congenital inability to experience pain.