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- Table of Contents
Facts about Sodium channel protein type 9 subunit alpha.
It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
Human | |
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Gene Name: | SCN9A |
Uniprot: | Q15858 |
Entrez: | 6335 |
Belongs to: |
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sodium channel (TC 1.A.1.10) family |
ETHA; FEB3B; NE-NA; NENAVoltage-gated sodium channel subunit alpha Nav1.7; Neuroendocrine sodium channel; Peripheral sodium channel 1; PN1hNE-Na; sodium channel protein type 9 subunit alpha; Sodium channel protein type IX subunit alpha; sodium channel, voltage-gated, type IX, alpha subunit; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated, type IX, alpha polypeptide
Mass (kDA):
226.372 kDA
Human | |
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Location: | 2q24.3 |
Sequence: | 2; NC_000002.12 (166195185..166375987, complement) |
Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection. In neurite terminals.
Despite its name SCN9A is an integral component of many biological assays. They provide resistance to antibiotics and complement auxotrophic disorders. Continue reading for more information about the SCN9A indicator. This article discusses the uses for SCN9A in biological science research. Learn how these markers can be helpful in your own research. Don't be afraid to share this article among your colleagues.
Boster Bio SCN9A is a versatile mRNA-capture microbead that has a diameter of between 10 and 95 mie. The microbeads may be used in a variety RNA-Seq assays. As the average expression level, this trajectory shows how these markers are expressed in 2D RNA. Markers are shown in clockwise order, and are used in many biological assays.
Bacillus subtilis has the SCN9A genes that are necessary for bacteria to display phenotypic properties. Two copy mutations within the rrs genes confer Spc immunity. These mutations confer resistance to Spc peptides of E. coli, Neisseria spp. and Nicotiana tabucum chromoplasts.
PMID: 7720699 by Klugbauer N., et al. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.
PMID: 17167479 by Cox J.J., et al. An SCN9A channelopathy causes congenital inability to experience pain.