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- Table of Contents
Facts about Sodium channel protein type 10 subunit alpha.
Plays a role in neuropathic pain mechanisms. .
Human | |
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Gene Name: | SCN10A |
Uniprot: | Q9Y5Y9 |
Entrez: | 6336 |
Belongs to: |
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sodium channel (TC 1.A.1.10) family |
hPN3; Nav1.8; PN3; sodium channel protein type 10 subunit alpha; sodium channel protein type X subunit alpha; sodium channel, voltage-gated, type X, alpha subunit; voltage-gated, type X, alpha polypeptide
Mass (kDA):
220.626 kDA
Human | |
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Location: | 3p22.2 |
Sequence: | 3; NC_000003.12 (38697110..38794010, complement) |
Expressed in the dorsal root ganglia and sciatic nerve.
Cell membrane; Multi-pass membrane protein. It can be translocated to the cell membrane through association with S100A10.
PMID: 9839820 by Rabert D.K., et al. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.
PMID: 23115331 by Faber C.G., et al. Gain-of-function Nav1.8 mutations in painful neuropathy.